894787-96-3 Usage
Molecular Class
Pyrimidinone
Functionality
Selective, dual inhibitor of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) signaling pathways
Purpose
Potential anti-cancer and anti-angiogenesis agent
Applications
Treatment of hepatocellular carcinoma, metastatic colorectal cancer, and other solid tumor types
Mechanism of Action
Inhibits the growth of new blood vessels needed for tumor growth and spread
Research Status
Shown promising results in preclinical and clinical studies, currently being investigated for potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 894787-96-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,7,8 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 894787-96:
(8*8)+(7*9)+(6*4)+(5*7)+(4*8)+(3*7)+(2*9)+(1*6)=263
263 % 10 = 3
So 894787-96-3 is a valid CAS Registry Number.
894787-96-3Relevant articles and documents
Chemical Process
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Page/Page column 17, (2008/12/08)
A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, (A chemical formula should be inserted here—please see paper copy enclosed herewith) I via a Heck reaction is described. Intermediates useful in the process and processes for making said intermediates are also described.
PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES
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Page/Page column 6; 22-23, (2010/11/25)
A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described. Novel intermediates and processes to make them are also described.
