894803-67-9

Basic information

• Product Name: 2,5-dimethoxy-4-methylthio-phenylethanol
• Synonyms: 2,5-dimethoxy-4-methylthio-phenylethanol;2,5-Dimethoxy-4-(methylthio)benzeneethanol;2-(2,5-dimethoxy-4-methylsulfanylphenyl)ethanol
• CAS NO: 894803-67-9
• Molecular Formula: C₁₁H₁₆O₃S
• Molecular Weight: 228.31
• Mol File: 894803-67-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 370.8°C at 760 mmHg
• Flash Point: 178°C
• Appearance: /
• Density: 1.17
• Vapor Pressure: 3.75E-06mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 2,5-dimethoxy-4-methylthio-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethoxy-4-methylthio-phenylethanol(894803-67-9)
• EPA Substance Registry System: 2,5-dimethoxy-4-methylthio-phenylethanol(894803-67-9)

Safety Data

• Hazardous Substances Data: 894803-67-9(Hazardous Substances Data)

Usage

General Description

2,5-dimethoxy-4-methylthio-phenylethanol is a chemical compound with the molecular formula C11H16O3S. It is a phenolic compound with two methoxy groups and a methylthio group attached to a phenylethanol backbone. 2,5-dimethoxy-4-methylthio-phenylethanol has potential applications in the field of medicinal chemistry, particularly as an intermediate in the synthesis of pharmaceuticals. It may also have properties suitable for use in perfumery or flavoring due to its aromatic nature. Additionally, the methylthio group may contribute to its biological activity, making it of interest to researchers studying its potential pharmacological properties. Further research is needed to fully understand the potential uses and effects of this compound.

InChI:InChI=1/C11H16O3S/c1-7(12)8-5-10(14-3)11(15-4)6-9(8)13-2/h5-7,12H,1-4H3

Upstream product

• 681171-56-2 [2-(4-bromo-2,5-dimethoxyphenyl)ethoxy]-tert-butyldimethylsilane 
• 184473-60-7 2-(4-bromo-2,5-dimethoxyphenyl)ethanol 

Downstream Products

• 894803-86-2 N-(4-amino-5-cyano-6-ethoxy-pyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxy-phenyl)-acetamide 
• 894803-69-1 (4-methanesulfonyl-2,5-dimethoxyphenyl)acetic acid 
• 894803-66-8 (4-methanesulfonyl-2,5-dimethoxyphenyl)acetyl chloride 
• 904311-61-1 2-(4-methanesulfonyl-2,5-dimethoxyphenyl)ethanol 

Relevant articles and documents

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer's disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ and showed little inhibitory activity against a panel of 74 kinases.