896134-06-8 Usage
Description
Donepezil Impurity is a chemical byproduct generated during the production of donepezil, a medication used to alleviate the symptoms of Alzheimer's disease. This impurity can impact the purity, efficacy, and safety of the final pharmaceutical product, necessitating stringent monitoring and control by manufacturers and regulatory bodies to ensure patient safety and product quality.
Uses
Donepezil Impurity does not have direct applications in any industry due to its nature as a byproduct and potential risk to patient safety. However, its presence in pharmaceutical products must be carefully managed to maintain product quality and safety. The primary use of monitoring and controlling Donepezil Impurity is to ensure the following:
Used in Pharmaceutical Industry:
Donepezil Impurity is managed as a quality control measure to maintain the purity and efficacy of donepezil medication for treating Alzheimer's disease.
Ensuring patient safety by minimizing the presence of impurities that could pose health risks.
Maintaining the overall quality of the final product by adhering to regulatory standards and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 896134-06-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,6,1,3 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 896134-06:
(8*8)+(7*9)+(6*6)+(5*1)+(4*3)+(3*4)+(2*0)+(1*6)=198
198 % 10 = 8
So 896134-06-8 is a valid CAS Registry Number.
896134-06-8Relevant articles and documents
Synthesis of new piperidyl indanone derivatives as anticonvulsant agents
Siddiqui, Nadeem,Arshad, M. Faiz,Khan, Suroor A.,Ahsan, Waquar,Ali, Ruhi,Alam, M. Shamsher,Ahmed, Sharique
, p. 726 - 733 (2012/10/18)
A series of 5,6-dimethoxy-2-{1-[arylamino/ alkylamino(thioxo)methyl]-4- piperidyl-methyl}-1-indanones (4a-l) were designed and synthesized by the reaction of 5,6-dimethoxy-2-(piperidin-4-yl-methyl)-indan-1-one with aryl/ alkyl isothiocyanates. The anticonvulsant activity was evaluated in animal models by maximal electroshock seizure and subcutaneous pentylenetetrazole tests. The neurotoxic effects were assessed by rotorod and ethanol potentiation tests. Gamma amino butyric acid (GABA) estimation of the selected compounds was performed in rat brain utilizing UV absorbance data. Compounds 4d, 4g, and 4j displayed encouraging anticonvulsant profile against both seizure models with remarkably lower neurotoxicity. These compounds were found to increase the GABA level in rat brain significantly. Springer Science+Business Media, LLC 2011.
