897-83-6 Usage
Description
DIETHYLUMBELLIFERYL PHOSPHATE is a chemical compound that serves as a substrate for lipase enzymes. It is commonly used in biochemical assays to measure lipase activity and has potential applications in various fields.
Uses
Used in Biochemical Assays:
DIETHYLUMBELLIFERYL PHOSPHATE is used as a substrate for lipase enzymes in biochemical assays to measure lipase activity. This allows researchers to study the function and regulation of lipases, which are important enzymes involved in the breakdown of lipids.
Used in In Vitro Neutrophil Differentiation Assays:
In the field of cell biology, DIETHYLUMBELLIFERYL PHOSPHATE is used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays. This application helps researchers understand the role of lipases in the differentiation and function of neutrophils, which are essential immune cells in the body.
Used in Pharmaceutical Research:
DIETHYLUMBELLIFERYL PHOSPHATE may also have potential applications in pharmaceutical research, particularly in the development of drugs targeting lipase enzymes. By studying the interactions between DIETHYLUMBELLIFERYL PHOSPHATE and lipases, researchers can gain insights into the design of novel therapeutic agents for various diseases.
Used in Food Industry:
In the food industry, DIETHYLUMBELLIFERYL PHOSPHATE could be used as a tool to study the lipase activity in various food products. This can help in understanding the role of lipases in food spoilage and developing strategies to control it, ultimately improving food quality and shelf life.
Used in Cosmetics Industry:
DIETHYLUMBELLIFERYL PHOSPHATE may also find applications in the cosmetics industry, where it can be used to study the lipase activity in skin and hair care products. This can help in developing formulations that maintain the integrity of lipids in the skin and hair, leading to improved product performance and benefits for consumers.
Biochem/physiol Actions
Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.
Check Digit Verification of cas no
The CAS Registry Mumber 897-83-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,9 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 897-83:
(5*8)+(4*9)+(3*7)+(2*8)+(1*3)=116
116 % 10 = 6
So 897-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
897-83-6Relevant articles and documents
Synthesis and anticancer activity of cyclotriphosphazenes functionalized with 4-methyl-7-hydroxycoumarin
Chen, Jipeng,Wang, Le,Fan, Yu,Yang, Yunxia,Xu, Mengsheng,Shi, Xiangyang
, p. 18316 - 18321 (2019)
As an important branch of heterocyclic compounds, coumarin and its derivatives with diverse potential biological activities have attracted wide attention and have been applied in medical-related fields. In this article, three cyclotriphosphazene derivatives bearing 4-methyl-7-hydroxycoumarin moieties with the numbers of 2, 4, and 6 were synthesized and characterized and their antitumor activities were investigated. All the new compounds were found to display antitumor activity in vitro against breast cancer cell lines (MCF-7 and 4T1 cells) with the IC50 values in the range of 108.72-188.44 μM and 75.93-154.91 μM, respectively. In contrast, the coumarin monomer displayed the values of 4140 μM and 1640 μM (IC50). Our results suggested that the antitumor activity was significantly enhanced when coumarin was introduced onto the surface of cyclotriphosphazenes, thereby providing potent candidate molecules for pharmaceutical applications.
Synthesis and anticholinesterase activity of some new fluorogenic analogues of organophosphorus nerve agents
Timperley, Christopher M.,Casey, Krystal E.,Notman, Stuart,Sellers, David J.,Williams, Nancy E.,Williams, Nichola H.,Williams, Gareth R.
, p. 1554 - 1563 (2008/09/18)
Eighteen new fluorogenic analogues of organophosphorus nerve agents were synthesised and characterised. They included analogues of tabun, sarin, cyclosarin, soman, VX, and Russian VX, with the 7-oxy-4-methylcoumarin or 7-oxy-4-(trifluoromethyl)coumarin leaving group. These analogues inhibited acetylcholinesterase (AChE) effectively in vitro and therefore have potential as tools for the identification of novel organophosphatases in biological systems. Analogues of VX and Russian VX with the 7-amino-4-methylcoumarin group, although poor AChE inhibitors, may have utility for screening enzyme libraries for phosphoramidases capable of cleaving P-N bonds.
