897314-72-6

Basic information

• Product Name: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropanamide
• Synonyms: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropanamide
• CAS NO: 897314-72-6
• Molecular Weight: 339.478
• Mol File: 897314-72-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropanamide(897314-72-6)
• EPA Substance Registry System: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropanamide(897314-72-6)

Safety Data

• Hazardous Substances Data: 897314-72-6(Hazardous Substances Data)

Upstream product

• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 106-44-5 p-cresol 
• 225943-09-9 diisopropyl 3-hydroxy-3-phenylpropanamide 

Downstream Products

• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 873551-03-2 (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate 
• 124937-52-6 tolterodine tartrate 
• 124937-51-5 (R)-(+)-tolterodine 

Relevant articles and documents

Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate

The invention concerns an improved process for the preparation of tolterodine (N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl propylamine) and its salts, in particular for the preparation of the tartrate salt, and more in particular for the (+)-(R) enantiomer of tolterodine L-tartrate, starting from a novel intermediate, N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide which can be used as pure Z or E isomer or as a mixture of Z and E isomers.

PROCESS FOR PREPARING TOLTERODINE AND THE L-TARTRATE THEREOF

The present invention relates to a process for preparing tolterodine and the L-tartrate thereof. The preparation consists of the following steps: A) ammonolysis reaction between diisopropylamine and compound 2 (3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-

A process for the preparation of tolterodine

A novel process for the preparation of tolterodine (I), i.e. (R)-N,N-diisopropyI-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.