89760-70-3

Basic information

• Product Name: L-Phenylalanine, N-[N-[(phenylmethoxy)carbonyl]-1-thio-L-a-aspartyl]-, 1-methyl 4-(phenylmethyl) ester
• CAS NO: 89760-70-3
• Molecular Formula: C29H30N2O6S
• Molecular Weight: 534.633
• Mol File: 89760-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[N-[(phenylmethoxy)carbonyl]-1-thio-L-a-aspartyl]-, 1-methyl 4-(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[N-[(phenylmethoxy)carbonyl]-1-thio-L-a-aspartyl]-, 1-methyl 4-(phenylmethyl) ester(89760-70-3)
• EPA Substance Registry System: L-Phenylalanine, N-[N-[(phenylmethoxy)carbonyl]-1-thio-L-a-aspartyl]-, 1-methyl 4-(phenylmethyl) ester(89760-70-3)

Safety Data

• Hazardous Substances Data: 89760-70-3(Hazardous Substances Data)

Upstream product

• 3479-47-8 Z-Asp(OBzl)-OH 
• 5262-07-7 Z-Asp(OBzl)-Phe-OMe 

Relevant articles and documents

STUDIES ON AMINO ACIDS AND PEPTIDES - VII SYNTHESES OF ASPARTAME AND THIOASPARTAME

The protected aspartame, 4, has been prepared from the benzyl ester of N-benzyloxycarbonyl-S-aspartic acid, 1, and the methyl S-phenylalanate, 3, using 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, LR, as a coupling reagent.Another protected aspartame, 7, has been prepared from the tert-butyl ester of 1--succinimide, 6, and methyl S-phenylalanate, 3.Thiations of 4/7 by LR produces a protected thioaspartame, 5/9.Deprotection of 7 and 9 gives aspartame, 8, and the slightly sweet thioaspartame, 10, in high yields.