89778-52-9

Basic information

• Product Name: 1-Pentanone, 5-hydroxy-1,2-diphenyl-
• CAS NO: 89778-52-9
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Mol File: 89778-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Pentanone, 5-hydroxy-1,2-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanone, 5-hydroxy-1,2-diphenyl-(89778-52-9)
• EPA Substance Registry System: 1-Pentanone, 5-hydroxy-1,2-diphenyl-(89778-52-9)

Safety Data

• Hazardous Substances Data: 89778-52-9(Hazardous Substances Data)

Upstream product

• 109-99-9 tetrahydrofuran 
• 100-59-4 phenylmagnesium chloride 
• 100-47-0 benzonitrile 

Downstream Products

• 25252-73-7 5,6-diphenyl-3,4-dihydro-2H-pyran 

Relevant articles and documents

Mn-catalyzed three-component reactions of imines/nitriles, grignard reagents, and tetrahydrofuran: An expedient access to 1,5-amino/keto alcohols

An expedient Mn-catalyzed three-component synthesis of 1,5-amino/keto alcohols from Grignard reagents, imines/nitriles, and tetrahydrofuran (THF) is described, which deviates from the classic Grignard addition to imines/nitriles in THF solvent. THF is split and sewn in an unprecedented manner in the reaction, leading to the formation of two geminal C-C bonds via C-H and C-O cleavage. Mechanistic experiments and DFT calculations reveal radical and organo-Mn intermediates in the catalytic cycle and the α-arylative ring-opening of THF as the key reaction step.