898257-48-2Relevant articles and documents
2 - Hydroxynaphthalene -1 - boric acid synthesis method (by machine translation)
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, (2019/02/19)
The invention discloses a 2 - hydroxynaphthalene - 1 - boric acid synthesis method, comprises the following steps: 1), 1 - bromo - 2 - naphthol synthetic; 2), hydroxy alkylated protection: [...], containing 1 - bromo - 2 - naphthol of the mixed solution, the heat of the reaction of dimethyl sulfate, shall be 1 - bromo - 2 - methoxy; 3), [...] boric acid-hydrogen substituted: 1 - bromo - 2 - methoxy, boric acid ester, such as n-butyllithium in the heat of the reaction, shall be 2 - armor chromene - 1 - boric acid; 4), demethylation reaction: 2 - armor chromene - 1 - boronic acid, boron tribromide after treatment after the reaction, a 2 - hydroxy - naphthalene - 1 - boric acid. The method of the invention can be a single high-purity, high yield of the target product, effectively solves the 2 - hydroxy - naphthalene - 1 - boric acid preparation process instability problems. (by machine translation)
