89836-93-1Relevant articles and documents
Deuterated pyrrolidone derivative Pharmaceutical compositions and uses thereof
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Paragraph 0077-0079, (2021/10/27)
The invention relates to a deuterated pyrrolidone derivative and a preparation method thereof, and also relates to application of the deuterated pyrrolidone derivative and a pharmaceutical composition thereof in treatment and prevention of metabolic disorder related diseases, and belongs to the field of medicines.
Development and Scale-Up of Stereoretentive α-Deuteration of Amines
Michelotti, Alessia,Rodrigues, Fabien,Roche, Maxime
supporting information, p. 1741 - 1744 (2017/11/24)
A stereoretentive deuteration of amino acids and amines has been developed using ruthenium on carbon catalyst, hydrogen gas at atmospheric pressure, and deuterium oxide as a source of deuterium. The process was successfully scaled-up, avoiding the use of expensive and sensitive catalyst and avoiding the use of deuterium gas under pressure. High deuterium incorporation and high yield of labeled compounds were obtained by a simple filtration process.
Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones
Oh, Joong-Suk,Kim, Kyung Il,Song, Choong Eui
supporting information; experimental part, p. 7983 - 7985 (2012/01/04)
Catalytic dynamic kinetic resolution (DKR) of racemic azlactones with EtOD using squaramide-based dimeric cinchona alkaloid organocatalysts is shown to be a highly effective strategy for the preparation of enantiomerically pure α-deuterated chiral α-amino
