898531-99-2

Basic information

• Product Name: PBS 57
• Synonyms: PBS 57;(15Z)-N-[(1S,2S,3R)-1-[[[6-(AcetylaMino)-6-deoxy-α-D-galactopyranosyl]oxy]Methyl]-2,3-dihydroxyheptadecyl]-15-tetracosenaMide;1-O-(6-acetamido-6-deoxy-alpha-D-galactosyl)-N-[(15Z)-tetracos-15-enoyl]phytosphingosine
• CAS NO: 898531-99-2
• Molecular Formula: C50H96N2O9
• Molecular Weight: 869.30524
• Product Categories: Carbohydrates & Derivatives;Fatty Acid Derivatives & Lipids;Glycerols
• Mol File: 898531-99-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PBS 57(CAS DataBase Reference)
• NIST Chemistry Reference: PBS 57(898531-99-2)
• EPA Substance Registry System: PBS 57(898531-99-2)

Safety Data

• Hazardous Substances Data: 898531-99-2(Hazardous Substances Data)

Usage

Description

PBS 57, also known as a galactosylceramide derivative, is a glycophytoceramide that consists of phytosphingosine having a 6-acetamido-6-deoxy-alpha-D-galactosyl attached at the O-1 position via a glycosidic linkage and a (Z)-tetracos-15-enoyl group attached to the nitrogen. It is a promising compound with potential applications in the field of medicine.
Used in Pharmaceutical Industry:
PBS 57 is used as an antiviral agent for the treatment of influenza. It has the ability to stimulate both a cell-mediated and humoral immune response, making it a valuable component in the development of vaccines and immunotherapies.
Used in Vaccine Development:
PBS 57 is used as an immune response enhancer in vaccine development. Co-administration of PBS-57 with a vaccine may be used in methods to stimulate one or more of a humoral immune response, a CD4+ T cell response, and a CD8+ cytotoxic T cell response, thereby improving the overall effectiveness of the vaccine.
Used in Immunotherapy:
PBS 57 is used as an immunotherapeutic agent to boost the immune system's response to infections and diseases. Its ability to stimulate both cell-mediated and humoral immune responses makes it a potential candidate for the development of novel immunotherapies targeting various diseases, including cancer and autoimmune disorders.

Upstream product

• 952301-28-9 C₇₅H₁₁₈N₂O₁₁ 
• 1769-00-2 1,2,3,4,6-penta-O-trimethylsilyl-α-D-galactose 
• 352432-47-4 2,3,4,6-tetra-O-tetramethylsilyl-α-D-galactopyranosyl iodide 
• 175696-50-1 tert-butyl [(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]carbamate 
• 145411-43-4 (Z)-tetracos-15-enoyl chloride 
• 506-37-6 Nervonic acid 
• 554-62-1 D-ribo-phytosphingosine 
• 75-36-5 acetyl chloride 
• 1260236-36-9 (2S,3S,4R)-2-amino-1-O-(6-deoxy-6-azido-α-D-galactopyranosyl)octadecane-3,4-diol 
• 1260236-35-8 (2S,3S,4R)-2-[(N-tert-butoxycarbonyl)amino]-1-O-(6-deoxy-6-azido-α-Dgalactopyranosyl)octadecane-3,4-diol 
• 1260236-39-2 (2S,3S,4R)-2-[(N-tert-butoxycarbonyl)amino]-3,4-di-tert-butyldimethylsilyloxy-1-O-(6-deoxy-6-azido-2,3,4-tri-O-trimethylsilyl-α-D-galactopyranosyl)octadecane 
• 1260236-38-1 (2S,3S,4R)-2-[(N-tert-butoxycarbonyl)amino]-3,4-di-tert-butyldimethylsilyloxy-1-O-(2,3,4-tri-O-trimethylsilyl-α-D-galactopyranosyl)octadecane 
• 1260236-37-0 (2S,3S,4R)-2-[(N-tert-butoxycarbonyl)amino]-3,4-di-tert-butyldimethylsilyloxy-1-O-(2,3,4,6-tetrakis-O-trimethylsilyl-α-D-galactopyranosyl)octadecane 
• 1001429-69-1 (1'S,2'S,3'R)-[2,3-bis-(tert-butyldimethylsilanyloxy)-1-(hydroxymethyl)heptadecyl]carbamic acid tert-butyl ester 

Relevant articles and documents

A comparison of benzyl and 2-naphthylmethyl ethers as permanent hydroxyl protecting groups in the synthesis of α-galactoglycosphingolipids KRN7000 and PBS-57

Due to the interest in the biological properties of marine derived α-galactoglycosphingolipids (α-GalGSLs), a lot of work has focused on the development of their synthesis. Here we conducted the direct comparison of benzyl and 2-naphthylmethyl (Nap) ether

MODIFIED -GALACTOSYL CERAMIDES FOR STAINING AND STIMULATING NATURAL KILLER T CELLS

Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.