89900-93-6

Basic information

• Product Name: METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE
• Synonyms: METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE;AKOS BAR-1970;Methyl 4-(3-nitrophenyl)benzoate;3'-nitro-[1,1'-biphenyl]-4-carboxylic acid methyl ester
• CAS NO: 89900-93-6
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.24
• Mol File: 89900-93-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 144-146°
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE(89900-93-6)
• EPA Substance Registry System: METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE(89900-93-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89900-93-6(Hazardous Substances Data)

Usage

General Description

METHYL 3'-NITRO[1,1'-BIPHENYL]-4-CARBOXYLATE, also known as Methyl 3'-nitrobiphenyl-4-carboxylate, is a chemical compound with the molecular formula C14H11NO4. It is a nitro-substituted biphenyl derivative, which is commonly used as a building block in the synthesis of various organic compounds. This chemical is often used in pharmaceutical and agrochemical research and development. It has a nitro group and a carboxylic acid ester group attached to a biphenyl structure, which makes it a valuable intermediate in the production of various chemical products. Due to its potential applications, it is important to handle and store this compound with care, following all necessary safety measures and protocols.

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 13331-27-6 m-nitrobenzene boronic acid 
• 1336-21-6 ammonium hydroxide 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 93-58-3 benzoic acid methyl ester 
• 16278-29-8 3-nitrobenzenediazonium 
• 67-56-1 methanol 
• 5737-85-9 3'-nitro-biphenyl-4-carboxylic acid 

Downstream Products

• 159503-24-9 3'-Amino-biphenyl-4-carboxylic acid methyl ester 
• 5737-85-9 3'-nitro-biphenyl-4-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of a novel photo-activated histone deacetylase inhibitor

Hydroxamic acid-based histone deacetylase inhibitors (HDACi) are a class of epigenetic agents with potentially broad therapeutic application to several disease states including post angioplasty mediated neointimal hyperplasia (NIH). Precise spatiotemporal

Aryldiazonium Tetrafluoroborate Salts as Green and Efficient Coupling Partners for the Suzuki-Miyaura Reaction: From Optimisation to Mole Scale

The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki-Miyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multivariate factor optimisation. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction, and one example was carried out on mole scale to demonstrate the practicality and scalability of the process.

Fast Suzuki-Miyaura cross-coupling reaction with hexacationic triarylphosphine Bn-dendriphos as ligand

The application of hexa[(dimethylamino)-methyl]-functionalized triphenylphosphine (1) and its benzylammonium salt, Bn-Dendriphos (2), in the Suzuki-Miyaura cross-coupling of aryl bromides with arylboronic acids is described. The 3,5-bis[(benzyldimethylammonio)methyl] substitution pattern in 2 leads to a rate enhancement compared to both the non-ionic parent compound 1 and triphenylphospine (PPh3) itself. At the same time, the resulting catalytic species are stable towards palladium black formation, even at a phosphine/palladium ratio of 1. These observations are attributed to the presence of a total of six ammonium groups in the backbone of the phosphine ligand, which presumably leads to an unsaturated phosphine-palladium complex.