89913-60-0 Usage
Description
(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid, also known as Acetyl-α-boswellic acid, is a pentacyclic triterpene and isomer of β-acetyl-boswellic acid originally isolated from B. serrata. It is characterized by the presence of an acetyloxy group at the 3alpha position and a carboxylic acid group at the 23 position. Acetyl-α-boswellic acid has been found to possess anti-inflammatory and anti-cancer properties, making it a promising candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Acetyl-α-boswellic acid is used as a selective inhibitor of COX-1, an enzyme involved in the synthesis of prostaglandins, which are known to play a role in inflammation and pain. By inhibiting COX-1, Acetyl-α-boswellic acid can help reduce inflammation and alleviate pain associated with various conditions.
Used in Anti-inflammatory Applications:
Acetyl-α-boswellic acid is used as an anti-inflammatory agent, particularly for conditions involving excessive inflammation such as arthritis, asthma, and inflammatory bowel disease. Its ability to inhibit LPS-induced TNF-α mRNA expression in monocytes and NF-κB activity in HEK293 cells makes it a potential therapeutic agent for managing inflammatory responses.
Used in Anti-cancer Applications:
Acetyl-α-boswellic acid is used as an anti-cancer agent, as it has been shown to inhibit the phosphorylation of IκBα mediated by IκB kinases (IKKs) in monocytes. This inhibition can help prevent the activation of NF-κB, a transcription factor that plays a crucial role in cell survival, proliferation, and resistance to apoptosis, which are key processes in cancer development and progression.
Check Digit Verification of cas no
The CAS Registry Mumber 89913-60-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,9,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 89913-60:
(7*8)+(6*9)+(5*9)+(4*1)+(3*3)+(2*6)+(1*0)=180
180 % 10 = 0
So 89913-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C32H50O4/c1-20(33)36-25-12-13-29(5)23-10-9-21-22-19-27(2,3)15-16-28(22,4)17-18-30(21,6)31(23,7)14-11-24(29)32(25,8)26(34)35/h9,22-25H,10-19H2,1-8H3,(H,34,35)/t22-,23+,24+,25+,28+,29+,30+,31+,32+/m0/s1
89913-60-0Relevant articles and documents
COMPOSITION FOR PREVENTING HAIR LOSS AND ACCELERATING HAIR GROWTH
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Paragraph 0017, (2015/10/05)
Disclosed is a composition for prevention of hair loss and promotion of hair growth. The composition includes a compound represented by Formula 1, wherein A is derived from polycyclic compounds, and R is a hydroxyl group, or a saturated or unsaturated straight or branched alkyloxy or acyloxy group having 1 to 20 carbon atoms.
