89937-77-9

Basic information

• Product Name: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
• Synonyms: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate;Methyl 2-hydroxypyridine-4-carboxylate;Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate 98%;4-Pyridinecarboxylicacid,1,2-dihydro-2-oxo-,methylester(9CI);Methyl 2-oxo-1,2-dihydropyridine-4-carboxylate;Methyl 2-hydroxypyridine-...;Methyl 2-hydroxypyridine-4-carboxylate, 1,2-Dihydro-4-(methoxycarbonyl)-2-oxopyridine;Methyl1,2-dihydro-2-oxopyridine-4-carboxylate98%
• CAS NO: 89937-77-9
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.13538
• Product Categories: CARBOXYLICESTER;blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 89937-77-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 211-212 °C
• Boiling Point: 342.4 °C at 760 mmHg
• Flash Point: 160.9 °C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 7.53E-05mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.02±0.10(Predicted)
• CAS DataBase Reference: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(89937-77-9)
• EPA Substance Registry System: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(89937-77-9)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN2811
• Hazardous Substances Data: 89937-77-9(Hazardous Substances Data)

Usage

General Description

Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an organic, aromatic compound classified under pyridones. It is also known with the systematic name 4Methoxycarbonyl-1,2-dihydropyridin-2-one. With a molecular formula of C8H9NO3, it contains carbon, hydrogen, nitrogen and oxygen atoms. This chemical plays a crucial role as an intermediate used in the synthesis of pharmaceuticals and agrochemicals. The substance is typically a liquid ranging from clear to light yellow in color. Although it is not widely studied, one should still follow safe handling protocols while using it.

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-2-3-8-6(9)4-5/h2-4H,1H3,(H,8,9)

Upstream product

• 3783-38-8 methyl isonicotinate N-oxide 
• 67-56-1 methanol 
• 22282-72-0 2-hydroxyisonicotinic acid 
• 1160938-15-7 methyl 2-(acetyloxy)-4-pyridinecarboxylate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 105596-63-2 2-methoxy-isonicotinic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 
• 13362-28-2 2-aminoisonicotinic acid 
• 6937-03-7 methyl 2-aminoisonicotinate 

Downstream Products

• 98140-91-1 2-hydroxy-isonicotinic acid hydrazide 
• 127838-58-8 4-hydroxymethylpyridin-2-ol 
• 127838-58-8 4-(hydroxymethyl)pyridin-2(1H)-one 
• 1245425-94-8 methyl 1-(4-methoxy-3-methylphenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1245425-86-8 methyl 1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 504-29-0 2-aminopyridine 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 918299-71-5 {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester 
• 105590-03-2 4-chloromethyl-pyridin-2-ol 
• 1072880-94-4 2-cyclohexylcarbamoyloxy-isonicotinic acid methyl ester 
• 98140-91-1 2-oxo-1,2-dihydropyridine-4-carbohydrazide 
• 74470-33-0 methoxycarbonyl-4 thiocarbonyl-2 dihydropyridine 
• 25504-47-6 methyl (RS)-2-oxopiperidine-4-carboxylate 

Relevant articles and documents

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

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cGAS ANTAGONIST COMPOUNDS

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TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.