90-49-3 Usage
Description
2-Phenylbutyrylurea is an organic compound that serves as a degradation product of Phenobarbitol (P316760) and is utilized in the synthesis and discovery of novel trypanosomicidal drug-like compounds.
Uses
Used in Pharmaceutical Industry:
2-Phenylbutyrylurea is used as a key intermediate in the synthesis and development of new trypanosomicidal drug-like compounds for the treatment of diseases caused by Trypanosoma parasites.
Used in Drug Discovery:
2-Phenylbutyrylurea is employed as a valuable building block in the discovery of novel therapeutic agents with potential trypanosomicidal activity, contributing to the advancement of treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 90-49-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90-49:
(4*9)+(3*0)+(2*4)+(1*9)=53
53 % 10 = 3
So 90-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15)
90-49-3Relevant articles and documents
Reactions of Carbonyl Diisocyanate with Amides and Acids
Akteries, Bernhard,Jochims, Johannes C.
, p. 669 - 682 (2007/10/02)
Carbonyl diisocyanate (1) reacts with primary amides to give 1-acylated isocyanuric acids (5, 6).With secondary amides, 1 affords the rather instable oxadiazinediones 4, which for certain substituents rearrange to give triazines (5, 10).With nucleophiles, compounds 4 give oligourets, e.g. with ureas pentaurets (11, 12) were obtained.Carbonyl diisocyanate reacts with hydrogen halides to afford the crystalline urea-1,3-dicarbonyl halides 13a-c.Diverse products (16, 17, 24, 26) were obtained with carboxylic acids.In most cases oxadiazinediones (26) were isolated, which can be transformed with nucleophiles into acyl ureas 30, 31, biurets 32, and triurets 33.Acetylation of 26 leads to the reactive heterocycles 34.