9001-04-1

Basic information

• Product Name: EC 4.1.1.1
• Synonyms: PYRUVATE DECARBOXYLASE;EC 4.1.1.1;2-OXO-ACID CARBOXY-LYASE;PYRUVATE DECARBOXYLASE FROM BAKERS YEAST;pyruvate decarboxylase from baker's yeast (s. cerevisiae);Pyruvate Decarboxylase, recombinant from E. coli
• CAS NO: 9001-04-1
• EINECS: 231-791-2
• Product Categories: Lyases;Specialty Enzymes
• Mol File: 9001-04-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: EC 4.1.1.1(CAS DataBase Reference)
• NIST Chemistry Reference: EC 4.1.1.1(9001-04-1)
• EPA Substance Registry System: EC 4.1.1.1(9001-04-1)

Safety Data

• WGK Germany: 2
• Hazardous Substances Data: 9001-04-1(Hazardous Substances Data)

Usage

Description

EC 4.1.1.1, also known as pyruvate decarboxylase, is an enzyme that catalyzes the decarboxylation of pyruvate to form acetaldehyde in the glycolytic pathway. It is found in various organisms, including baker's yeast (S. cerevisiae). Pyruvate decarboxylase plays a crucial role in the conversion of pyruvate to acetaldehyde, which is an essential step in the production of ethanol and other bioproducts.
Source:
Pyruvate decarboxylase is typically found in yeast, such as Saccharomyces cerevisiae, and other organisms that utilize the glycolytic pathway for energy production and bioproduct synthesis.
Production Methods:
Pyruvate decarboxylase is produced by the expression of the corresponding gene in the host organism. In yeast, the gene encoding pyruvate decarboxylase is regulated by various factors, including the availability of nutrients and environmental conditions.

Uses

Used in Metabolic Engineering:
EC 4.1.1.1 is used as a key enzyme in metabolic engineering for the production of bioproducts such as ethanol, acetate, and other organic compounds. By modifying the expression levels and regulation of pyruvate decarboxylase, researchers can optimize the metabolic pathways and increase the yield of desired products.
Used in Yeast Strain Development:
Pyruvate decarboxylase is used in the development of yeast strains with improved performance in industrial fermentation processes. By engineering yeast strains with enhanced pyruvate decarboxylase activity, the efficiency of bioproduct production can be increased, leading to higher yields and reduced production costs.
Used in Systems Biology Research:
EC 4.1.1.1 has been used to evaluate the power of systematic identification of meaningful metabolic enzyme regulation (SIMMER) for finding unknown yeast regulatory interactions. This research helps to better understand the complex regulatory networks in yeast and other organisms, which can be applied to improve the performance of industrial strains and optimize bioprocesses.

Biochem/physiol Actions

Pyruvate decarboxylase?(PDC) actively participates in the anaerobic metabolism?of several bacteria, yeast and?plant seeds.