9001-45-0 Usage
Description
β-Glucuronidase is an enzyme that catalyzes the hydrolysis of β-glucuronides, which are important in the metabolism and excretion of various compounds, including drugs and steroids. It is widely distributed in nature and can be found in various organisms, such as bacteria, fungi, and plants.
Uses
Used in Molecular Biology:
β-Glucuronidase is used as a reporter gene in GUS assays to monitor gene expression. This allows researchers to study the regulation of gene expression and the function of promoters in various organisms.
Used in Pharmaceutical Industry:
β-Glucuronidase was used in the study of Cer-β-glucuronide synthesis and evaluation of β-glucuronidase(s) from Escherichia coli or intestinal segments to release the head group. This helps in understanding the metabolism and bioavailability of drugs and other compounds.
Used in Clinical Chemistry:
In the determination of urinary steroids and of steroid conjugates in blood, β-glucuronidase plays a crucial role. It aids in the analysis of steroid levels, which can be important for diagnosing various endocrine disorders and monitoring treatment efficacy.
Biochem/physiol Actions
β-Glucuronidase (GUSB) is a lysosomal enzyme, that degrades glucuronate-containing glycosaminoglycans. β-glucuronidase, obtained from abalone has the ability to hydrolyze samples, that has high analyte concentrations. Absence of β-glucuronidase results in mucopolysaccharidosis type VII (MPSVII), which leads to lysosomal storage in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 9001-45-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 9001-45:
(6*9)+(5*0)+(4*0)+(3*1)+(2*4)+(1*5)=70
70 % 10 = 0
So 9001-45-0 is a valid CAS Registry Number.
