9001-88-1

Basic information

• Product Name: PHOSPHORYLASE KINASE
• Synonyms: ATP: PHOSPHORYLASE-B PHOSPHOTRANSFERASE;DEPHOSPHOPHOSPHORYLASE KINASE;EC 2.7.1.38;PHOSPHORYLASE KINASE;phosphorylase kinase from rabbit muscle;ATP:phosphorylase-b phosphotransferase, Dephosphophosphorylase kinase
• CAS NO: 9001-88-1
• Molecular Weight: 0
• Mol File: 9001-88-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: PHOSPHORYLASE KINASE(CAS DataBase Reference)
• NIST Chemistry Reference: PHOSPHORYLASE KINASE(9001-88-1)
• EPA Substance Registry System: PHOSPHORYLASE KINASE(9001-88-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 9001-88-1(Hazardous Substances Data)

Usage

Description

Phosphorylase kinase is a complex enzyme composed of four subunits, each containing an α, β, γ, and sigma component. The sigma component, known as calmodulin, binds four calcium molecules, while the γ unit serves as the catalytic subunit. This enzyme plays a crucial role in the regulation of glycogen metabolism by catalyzing the phosphorylation of glycogen phosphorylase, thereby activating it and promoting glycogen breakdown.

Uses

Used in Biochemical Research:
Phosphorylase kinase is used as a research tool for studying the regulation of glycogen metabolism and the activation of glycogen phosphorylase. It has been employed in various studies to assess the features of glycogen phosphorylase and to investigate the activation of different forms of muscle phosphorylase kinase by actin.
Used in Pharmaceutical Industry:
Phosphorylase kinase may have potential applications in the development of drugs targeting glycogen metabolism-related disorders. By understanding the enzyme's role in the regulation of glycogen breakdown, researchers can potentially develop therapeutic agents that modulate its activity, leading to the treatment of conditions such as glycogen storage diseases or muscle disorders associated with impaired glycogen metabolism.
Used in Diagnostic Applications:
Phosphorylase kinase could be utilized in diagnostic assays to evaluate the activity of glycogen phosphorylase and monitor the effectiveness of treatments targeting glycogen metabolism. This may help in the early detection and management of related disorders, as well as in the assessment of the patient's response to therapy.