900186-75-6 Usage
Description
5-Nitro-1-cyclohexene-1-carboxaldehyde is an organic compound characterized by the presence of a nitro group attached to a cyclohexene ring and a formyl group attached to the carbon atom. It is a yellow crystalline solid with a molecular formula of C7H9NO3.
Uses
Used in Pharmaceutical Industry:
5-Nitro-1-cyclohexene-1-carboxaldehyde is used as a reactant in the synthesis of himbacine analogs, which are thrombin receptor antagonists. These analogs have potential applications in the treatment of various cardiovascular and thrombotic disorders, such as deep vein thrombosis, pulmonary embolism, and acute coronary syndrome.
In the synthesis process, 5-Nitro-1-cyclohexene-1-carboxaldehyde serves as a key intermediate, contributing to the formation of the desired himbacine analogs with specific structural features and biological activities. The development of these analogs can lead to the discovery of novel therapeutic agents with improved efficacy, safety, and pharmacokinetic properties, ultimately benefiting patients with thrombotic and cardiovascular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 900186-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,1,8 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 900186-75:
(8*9)+(7*0)+(6*0)+(5*1)+(4*8)+(3*6)+(2*7)+(1*5)=146
146 % 10 = 6
So 900186-75-6 is a valid CAS Registry Number.
900186-75-6Relevant articles and documents
EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS
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Page/Page column 34-35, (2008/06/13)
The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught her
