900186-89-2

Basic information

• Product Name: C₂HF₃O₂*C₆H₆BrNO
• Synonyms: C₂HF₃O₂*C₆H₆BrNO
• CAS NO: 900186-89-2
• Molecular Weight: 302.048
• Mol File: 900186-89-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂HF₃O₂*C₆H₆BrNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂HF₃O₂*C₆H₆BrNO(900186-89-2)
• EPA Substance Registry System: C₂HF₃O₂*C₆H₆BrNO(900186-89-2)

Safety Data

• Hazardous Substances Data: 900186-89-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 31181-64-3 5-bromo-2-methyl-pyridine-N-oxide 

Downstream Products

• 88139-91-7 (5-bromopyridin-2-yl)methanol 

Relevant articles and documents

Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate

This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: wherein R9 is selected from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms, and R11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, X2 is Cl, Br, or I; X3 is selected from Cl and Br; and PdLn is a supported palladium metal catalyst or a soluble heterogeneous palladium catalyst. The L-derivatizing reagent is a moiety which converts the alcohol functional group of compound 137D to any leaving group which can be displaced by a triorgano-phosphite phosphonating agent.