9004-06-2 Usage
Description
Elastase is a proteolytic enzyme that is primarily found in human leukocytes and is involved in the degradation of elastin, a protein found in connective tissues. It plays a crucial role in various physiological processes, including tissue remodeling, wound healing, and immune response.
Uses
Used in Medical Research:
Elastase is used as a research tool for measuring serum elastase activity, which can be an indicator of certain diseases or conditions. It is also used in proteolytic digestion of fibronectin and salivary glands to study the presence of fibronectin peptides in saliva of patients with Sj?gren's syndrome.
Used in Pharmaceutical Industry:
Elastase is used in neutrophil elastase (NE) activity assays to determine the presence and activity of NE in cell lysates. This is important for understanding the role of NE in various diseases and for developing potential therapeutic agents.
Used in Wound Healing Studies:
Elastase has been used in scratch wound assays to study the effect of certain compounds on wound healing. It helps in understanding the role of elastase in tissue repair and regeneration.
Used in Angiogenesis Research:
In a study, fragments of Nle3-angiotensin(1-7) were found to accelerate healing in dermal models. Elastase was used in this study to digest E-cadherin, a protein involved in cell adhesion, to investigate the underlying mechanisms of the healing process.
Used in Cancer Research:
Elastase has been used in a study examining the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells from patients with acute promyelocytic leukemia. This research helps in understanding the role of elastase in cancer progression and the potential therapeutic effects of all-trans retinoic acid.
Biochem/physiol Actions
Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin.
Check Digit Verification of cas no
The CAS Registry Mumber 9004-06-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 9004-06:
(6*9)+(5*0)+(4*0)+(3*4)+(2*0)+(1*6)=72
72 % 10 = 2
So 9004-06-2 is a valid CAS Registry Number.
