900513-65-7

Basic information

• Product Name: 2,5-ANHYDRO-6-AZIDO-4,6-DIDEOXY-4-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-1-(DIMETHYL ACETAL)-L-MANNOSE
• Synonyms: 2,5-ANHYDRO-6-AZIDO-4,6-DIDEOXY-4-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-1-(DIMETHYL ACETAL)-L-MANNOSE
• CAS NO: 900513-65-7
• Molecular Formula: C13H19N5O6
• Molecular Weight: 341.322
• Mol File: 900513-65-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-ANHYDRO-6-AZIDO-4,6-DIDEOXY-4-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-1-(DIMETHYL ACETAL)-L-MANNOSE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-ANHYDRO-6-AZIDO-4,6-DIDEOXY-4-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-1-(DIMETHYL ACETAL)-L-MANNOSE(900513-65-7)
• EPA Substance Registry System: 2,5-ANHYDRO-6-AZIDO-4,6-DIDEOXY-4-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-1-(DIMETHYL ACETAL)-L-MANNOSE(900513-65-7)

Safety Data

• Hazardous Substances Data: 900513-65-7(Hazardous Substances Data)

Usage

Molecular structure

A complex sugar derivative with multiple functional groups, including azide, dideoxy, pyrimidinyl, and acetal.

Origin

Derived from L-mannose, a naturally occurring sugar.

Potential applications

Glycochemistry, biochemistry, and medicinal chemistry.

Unique structure

The compound has a distinct structure that sets it apart from other sugar derivatives.

Biological activity

Possesses potential biological activity, which may be harnessed for various applications in the fields of research and medicine.

Research necessity

Further research is needed to fully understand the properties and potential uses of this chemical.

Upstream product

• 196596-85-7 2,5-anhdyro-4-deoxy-4-(thymin-1-yl)-L-mannofuranose dimethyl acetal 

Relevant articles and documents

Studies on modified oligonucleotides

A series of isonucleotide incorporated antisense oligodeoxynucleotides have been synthesized, in which isonucleotide was introduced at different positions of the sequences. The results showed that though the incorporated isonucleotides at different position of the sequence interfered in the binding ability in different extent, B-form duplexes were maintained and the binding abilities of the 3′-end modified duplexes were better than the corresponding mismatched duplexes. The DNA/RNA hybrid formed by modified oligodeoxynucleotide and its target RNA could activate the activity of RNase H. The 3′-end modified antisense oligodeoxynucelotides showed the inhibition on S glycoprotein expression of SARS-CoV at the mRNA levels in insect Sf9 cells. In this presentation, a novel class of amino-isonucleoside was synthesized and incorporated into different positions in the sense or antisense strand of siRNA duplexes. The 3′ and 5′ sense strand aminonucleoside modified siRNAs (ssISO-siRNA1 and ssISO-siRNA2) showed the similar duplex thermal and serum stability as natural one and the luciferase activities showed that such modified siRNA is compatible with the intracellular siRNA machinery. Copyright Taylor & Francis Group, LLC.