90065-66-0

Basic information

• Product Name: 1-Methyl-7-deazaguanine
• Synonyms: 1-Methyl-7-deazaguanine;2-AMINO-7-METHYL-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE
• CAS NO: 90065-66-0
• Molecular Formula: C₇H₈N₄O
• Molecular Weight: 164.167
• Mol File: 90065-66-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-7-deazaguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-7-deazaguanine(90065-66-0)
• EPA Substance Registry System: 1-Methyl-7-deazaguanine(90065-66-0)

Safety Data

• Hazardous Substances Data: 90065-66-0(Hazardous Substances Data)

Usage

Description

1-Methyl-7-deazaguanine is a modified purine nucleotide that is a derivative of guanine, one of the four standard nucleobases in DNA and RNA. 1-Methyl-7-deazaguanine features a methyl group attached to the nitrogen atom at position 1 and lacks the traditional nitrogen at position 7, which distinguishes it as "7-deazaguanine." The structural alteration impacts its hydrogen bonding properties, influencing interactions with other nucleotides and proteins. It is present in various microorganisms and is a component of specific enzymes and coenzymes, such as queuine tRNA-ribosyltransferase and the coenzyme queuine. 1-Methyl-7-deazaguanine holds promise for pharmaceutical applications and the advancement of nucleic acid-based technologies.

Uses

Used in Pharmaceutical Development:
1-Methyl-7-deazaguanine is utilized as a pharmaceutical compound due to its unique structure and properties, which may offer therapeutic benefits in various medical applications.
Used in Enzyme and Coenzyme Components:
In the microorganism industry, 1-Methyl-7-deazaguanine serves as a component of enzymes and coenzymes, such as the enzyme queuine tRNA-ribosyltransferase and the coenzyme queuine, playing a crucial role in their functions.
Used in Nucleic Acid-based Technologies:
1-Methyl-7-deazaguanine is employed in the development of new nucleic acid-based technologies, leveraging its distinct chemical properties to enhance or create innovative applications in molecular biology and genetic research.

Upstream product

• 107-20-0 2-chloroethanal 
• 54004-20-5 2-amino-6-(methylamino)pyrimidin-4(3H)-one 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 90065-74-0 2-amino-4-<(2-hydroxyethyl)thio>-7-methyl-7H-pyrrolo<2,3-d>pyrimidine 
• 84955-33-9 2-amino-4-methoxy-7-methyl-7H-pyrrolo<2,3-d>pyrimidine 
• 54004-20-5 2-amino-4-hydroxy-6-methylaminopyrimidine 
• 90065-71-7 2-amino-4-chloro-7-methyl-7H-pyrrolo<2,3-d>pyrimidine 

Relevant articles and documents

Isomeric N-methyl-7-deazaguanines: Synthesis, structural assignment, and inhibitory activity on xanthine oxidase

The N-methyl isomers of 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one1 (2a) have been synthesized regiospecifically and their structures assigned. The 3-methyl thylcompound was obtained by alkylation of the parent chromophore 2a with dim

Discovery of pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor

A new class of pyrrolo[2,3-d]pyrimidin-4-one corticotropin-releasing factor 1 (CRF1) receptor antagonists has been designed and synthesized. In general, reported CRF1 receptor antagonists possess a sp 2-nitrogen atom as hy

The synthesis and determination of acidic ionization constants of certain 5-substituted 2-aminopyrrolo[2,3-d]pyrimidin-4-ones and methylated analogs

The acidic ionization constants were determined for a series of 5-substituted 2-aminopyrrolo[2,3-dl-pyrimidin-4-ones and N-3- and N-7-methylated analogs thereof. The syntheses of the methylated analogs are also described.