9007-41-4

Basic information

• Product Name: C-REACTIVE PROTEIN, HUMAN
• Synonyms: RHCRP;CRP, HUMAN;CRP HUMAN SERUM;CRP;C-REACTIVE PROTEIN, HUMAN;C-REACTIVE PROTEIN, HUMAN ASCITES;C-REACTIVE PROTEIN, HUMAN, RECOMBINANT;C-REACTIVE PROTEIN HUMAN SERUM
• CAS NO: 9007-41-4
• Molecular Weight: 0
• Product Categories: proteins
• Mol File: 9007-41-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: ~100 °C
• Appearance: /buffered aqueous solution
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C-REACTIVE PROTEIN, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: C-REACTIVE PROTEIN, HUMAN(9007-41-4)
• EPA Substance Registry System: C-REACTIVE PROTEIN, HUMAN(9007-41-4)

Safety Data

• Hazard Codes: Xn,B
• Statements: 20/21/22-32-21/22-22
• Safety Statements: 36/37-7
• RIDADR: UN 3264 8 / PGIII
• Hazardous Substances Data: 9007-41-4(Hazardous Substances Data)

Usage

Description

C-Reactive Protein, Human is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. It is composed of five identical noncovalently linked subunits and exhibits Ca2+-dependent binding to a variety of substrates. Important in the diagnosis of rheumatoid arthritis, it is suitable for immunological studies. In purified states and in plasma, the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Uses

Used in Immunological Applications:
C-Reactive Protein, Human is used as an immunological agent for the preparation of antisera, which helps in the study and diagnosis of various diseases and conditions.
Used in Diagnostic Applications:
C-Reactive Protein, Human is used in the Human C-Reactive Protein ELISA Kit for measuring C-reactive protein (CRP) levels in serum. This measurement is crucial for monitoring inflammation, infection, and other acute-phase conditions, as well as diagnosing rheumatoid arthritis and other autoimmune diseases.
Used in Research Applications:
C-Reactive Protein, Human is used as a research tool for studying the mechanisms of acute-phase responses, inflammation, and immune system regulation. It aids in understanding the role of CRP in various pathological processes and contributes to the development of new therapeutic strategies and diagnostic tools.

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.