9007-83-4

Basic information

• Product Name: GLOBULINS, CAT GAMMA
• Synonyms: MOUSE GAMMA GLOBULIN;MOUSE GAMMA-GLOBULIN, SERUM;CAT GAMMA GLOBULIN;HORSE GAMMA GLOBULIN;GLOBULINS, CAT GAMMA;GLOBULINS, HORSE GAMMA;GLOBULINS, MOUSE GAMMA;GAMMA-GLOBULIN MOUSE
• CAS NO: 9007-83-4
• Molecular Weight: 0
• EINECS: 232-706-1
• Product Categories: GlobulinsApplication Index;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins;Serum Proteins and Related Enzymes;Globulins
• Mol File: 9007-83-4.mol
• Article Data: 0

Chemical Properties

• Appearance: Colorless/
• Storage Temp.: −20°C
• Solubility: 0.05 M phosphate buffer, pH 7.0: 10 mg/mL, slightly hazy, c
• CAS DataBase Reference: GLOBULINS, CAT GAMMA(CAS DataBase Reference)
• NIST Chemistry Reference: GLOBULINS, CAT GAMMA(9007-83-4)
• EPA Substance Registry System: GLOBULINS, CAT GAMMA(9007-83-4)

Safety Data

• Hazard Codes: B,Xn
• Statements: 22
• WGK Germany: 3
• RTECS: LZ3450000
• F: 10-21
• Hazardous Substances Data: 9007-83-4(Hazardous Substances Data)

Usage

Description

GLOBULINS, CAT GAMMA, also known as γ-Globulins, are a class of proteins composed of four polypeptide chains, with two having molecular weights of approximately 50,000 and two of about 20,000. These chains are interconnected by disulfide bonds, forming a complex structure. They have been utilized in various applications across different fields, particularly in biological and medical research.

Uses

Used in Pharmaceutical and Biomedical Research:
GLOBULINS, CAT GAMMA from mouse were employed as a crucial component in the development and validation of an enzyme-linked immunosorbent assay (ELISA) for detecting Herceptin levels in human serum. This application aids in monitoring the presence and effectiveness of Herceptin, a therapeutic monoclonal antibody used in cancer treatment.
Used in Lipid Metabolism Studies:
GLOBULINS, CAT GAMMA from sheep have been utilized in studies examining the impact of high-density lipoprotein (HDL) cholesterol-raising drugs on the in vitro activity of the HDL receptor SR-BI. This research is vital for understanding the role of HDL cholesterol in lipid metabolism and its influence on cardiovascular health.
Used in Tissue Engineering and Transport Studies:
In a separate study, GLOBULINS, CAT GAMMA from sheep were used to investigate the interstitial transport of rabbit and sheep antibodies in both normal and neoplastic tissues. This research is essential for advancing tissue engineering and developing targeted drug delivery systems.
Used in Endocrinology and Reproductive Biology:
GLOBULINS, CAT GAMMA have also been applied in studies focused on endocrinology and reproductive biology. They were used to test the effects of certain conditions on progesterone and testosterone secretion, as well as the suppression of estradiol secretion in small white follicle cells of incubating turkey hens. This research contributes to a better understanding of hormonal regulation and reproductive processes in animals.

Biochem/physiol Actions

Immunoglobulins are key regulators of the immune system and are produced in response to antigens. They protect our bodies against bacteria, viruses, and fungi. Immunoglobulins are involved in the activation of the complement system, opsonization of microbes for phagocytosis, neutralization of toxins and viruses, and inhibition of the attachment of microbes to mucosal surfaces. Immunodeficiency can lead to recurrent infectious diseases.