90102-88-8Relevant articles and documents
Synthetic Studies with 4-benzaldehyde: A New Synthesis of Phenylalanine Mustard
Sen, A.K.,Mukhopadhyay, Sankardeb
, p. 939 - 941 (2007/10/02)
A new synthesis of the anticancer drug, 4-phenylalanine (phenylalanine mustard) (I) from 4-benzylidene>-2-phenyl-2-oxazoline-5-one (V) is described.V in turn has been obtained by condensation of 2-phenyl-2-oxazolin-5-one with 4-benzylidene>-4'-N,N-dimethylaminoaniline (III).Condensation of III or 4-benzaldehyde (II) with imidazolidine-2,4-dione (VIII) affords 5-benzylidene>imidazolidine-2,4-dione (X) which onreduction followed by hydrolysis gives 4-phenylalanine (XII).