90205-46-2

Basic information

• Product Name: Glycine, N-(1-oxobutyl)-,ethyl ester
• Synonyms: Glycine, N-(1-oxobutyl)-,ethyl ester
• CAS NO: 90205-46-2
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 0
• Mol File: 90205-46-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Glycine, N-(1-oxobutyl)-,ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(1-oxobutyl)-,ethyl ester(90205-46-2)
• EPA Substance Registry System: Glycine, N-(1-oxobutyl)-,ethyl ester(90205-46-2)

Safety Data

• Hazardous Substances Data: 90205-46-2(Hazardous Substances Data)

Upstream product

• 106-31-0 butanoic acid anhydride 
• 623-33-6 glycine ethyl ester hydrochloride 
• 141-75-3 butyryl chloride 
• 459-73-4 GlyOEt*HCl 

Downstream Products

• 20208-73-5 N-butyrylglycine 
• 1626437-83-9 N-(3-(1-butyryl-2,4-dioxopyrrolidin-3-ylidene)-3-hydroxypropyl)-4-methylbenzenesulfonamide 
• 1527499-46-2 1-butyryl-3-(1-hydroxy-3-(4-(methylthio)phenyl)propylidene)pyrrolidine-2,4-dione 
• 1100753-82-9 C₁₆H₂₄N₂O₂ 
• 937-52-0 (R)-1-methyl-3-phenylpropylamine 
• 90087-72-2 5-Aethoxy-2-propyl-oxazol 
• 132129-03-4 (N-butyryl-glycyl)-(toluene-4-sulfonyl)-amine 
• 98278-67-2 N-butyryl-glycine hydrazide 

Relevant articles and documents

A detailed study of antibacterial 3-acyltetramic acids and 3-acylpiperidine-2,4-diones

Inspired by the core fragment of antibacterial natural products such as streptolydigin, 3-acyltetramic acids and 3-acylpiperidine-2,4-diones have been synthesised from the core heterocycle by direct acylation with the substituted carboxylic acids using a strategy which permits ready access to a structurally diverse compound library. The antibacterial activity of these systems has been established against a panel of Gram-positive and Gram-negative bacteria, with activity mostly against the former, which in some cases is very potent. Data consistent with modes of action against undecaprenylpyrophosphate synthase (UPPS) and/or RNA polymerase (RNAP) for a small subset of the library has been obtained. The most active compounds have been shown to exhibit binding at known binding sites of streptolydigin and myxopyronin at UPPS and RNAP. These systems offer potential for their antibacterial activity, and further demonstrate the use of natural products as biologically validated starting points for drug discovery.

Ruthenium Tetroxide Oxidation of N-Acylated Alkylamines: A New General Synthesis of Imides

Oxidation of various N-acylalkylamines with ruthenium tetroxide (RuO4) was systematically investigated.N-acylalkylamines having an electron-donating group at the α- or β-position with respect to amide nitrogen or an electron-donating alkyl function in the acyl group were smoothly oxidized to the corresponding imides in excellent yields.On the other hand, N-acylalkylamines having an electron-withdrawing group were not oxidized at all, and most of the starting material was recovered.It appears that the reactivity of N-acylalkylamines is closely correlated with the acidity of the carboxylic acid from which the N-acyl group is derived, and also with the electron density at the methylene moiety adjacent to the amide nitrogen atom.Keywords---oxidation; ruthenium tetroxide oxidation; imide synthesis; acyclic imide; amide; ruthenium tetroxide; substituent effect