90226-22-5

Basic information

• Product Name: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine
• Synonyms: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine
• CAS NO: 90226-22-5
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.22728
• Mol File: 90226-22-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 157.641°C at 760 mmHg
• Flash Point: 35.326°C
• Appearance: /
• Density: 0.842g/cm³
• Vapor Pressure: 2.728mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine(90226-22-5)
• EPA Substance Registry System: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine(90226-22-5)

Safety Data

• Hazardous Substances Data: 90226-22-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H17N/c1-7-4-3-5-8(6-7)9-2/h7-9H,3-6H2,1-2H3

Upstream product

• 64-18-6 formic acid 
• 590-29-4 potassium formate 
• 108249-54-3 1,2,6-trimethyl-pyridinium; bromide 
• 74-89-5 methylamine 
• 591-24-2 3-Methylcyclohexanone 
• 13368-65-5 (3R)-3-methylcyclohexanone 

Downstream Products

• 252853-22-8 N-methyl-N-(3-methylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Relevant articles and documents

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE

The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.