902456-04-6

Basic information

• Product Name: [4-(2,3-dichloro-phenyl)-4-oxy-piperazin-1-yl]-phenyl-methanone
• Synonyms: [4-(2,3-dichloro-phenyl)-4-oxy-piperazin-1-yl]-phenyl-methanone
• CAS NO: 902456-04-6
• Molecular Weight: 351.232
• Mol File: 902456-04-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(2,3-dichloro-phenyl)-4-oxy-piperazin-1-yl]-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2,3-dichloro-phenyl)-4-oxy-piperazin-1-yl]-phenyl-methanone(902456-04-6)
• EPA Substance Registry System: [4-(2,3-dichloro-phenyl)-4-oxy-piperazin-1-yl]-phenyl-methanone(902456-04-6)

Safety Data

• Hazardous Substances Data: 902456-04-6(Hazardous Substances Data)

Upstream product

• 902456-03-5 [4-(2,3-dichloro-phenyl)-piperazin-1-yl]-phenyl-methanone 
• 119532-26-2 1-(2,3-dichlorophenyl)-piperazine hydrochloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 573691-11-9 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl (4-N-oxo)]butoxy}3,4-dihydro-2(1H)-quinolinone 
• 902456-05-7 1-(2,3-dichloro-phenyl)-piperazine 1-oxide 

Relevant articles and documents

Synthesis and characterization of N-oxides and metabolites of anti-psychotic drug, Aripiprazole

Aripiprazole is a recently developed anti-psychotic drug used for the treatment of schizophrenia. Aripiprazole and its N-oxides exhibit a strong activity for influencing the neurotransmission of dopamine receptors and are devoid of side effects induced by the known drugs useful for the treatment of schizophrenia. Further, Aripiprazole is metabolized by different biotransformation pathways as dehydrogenation, hydroxylation and N-dealkylation giving rise to different metabolites. The present work details the development of a simple and novel process for the preparation of Aripiprazole N-oxides as Aripiprazole-4-N-oxide, Aripiprazole-1-N-oxide and Aripiprazole-1,4-di-N-oxide and Aripiprazole metabolites such as dehydro Aripiprazole and Aripiprazole hydroxy metabolite.