90251-33-5Relevant articles and documents
Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
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, (2008/06/13)
Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preperation, their use as medicaments, their use as diagnostic agents and medicaments containing them. Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I STR1 where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a --CO--N=C(NH2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, NO2, N3, (C1 -C4)-alkoxy, CF3 ; up to one of the other substituents is R(8)--Cn H2n --Z-- or phenyl; R(7) is H, alk(en)yl or R(8)--Cn H2n --, and pharmaceutically tolerated salts there of, are described. A process f or the preparation of the compounds I which comprises reacting a compound of the formula II STR2 in which one of the substituents R(1)' to R(5)' is a --CO--L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmacologically tolerated salt, furthermore is also described.
A convenient synthesis of 3,5-disubstituted 2-acetylindoles
Rajur,Merwade,Basanagoudar
, p. 421 - 428 (2007/10/02)
An easy synthesis of 3,5-disubstituted-2-actylindoles by the HCl cyclization of the corresponding phenylhydrazones is described.
