902757-07-7

Basic information

• Product Name: BORONIC ACID, [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]-
• Synonyms: [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]BORONIC ACID;BORONIC ACID, [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]-
• CAS NO: 902757-07-7
• Molecular Formula: C₇H₅BClF₃O₃
• Molecular Weight: 240.37
• Mol File: 902757-07-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 177-179 °C
• Boiling Point: 292.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.20±0.10(Predicted)
• CAS DataBase Reference: BORONIC ACID, [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: BORONIC ACID, [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]-(902757-07-7)
• EPA Substance Registry System: BORONIC ACID, [4-CHLORO-3-(TRIFLUOROMETHOXY)PHENYL]-(902757-07-7)

Safety Data

• Hazardous Substances Data: 902757-07-7(Hazardous Substances Data)

Upstream product

• 406232-79-9 4-bromo-1-chloro-2-(trifluoromethyloxy)benzene 
• 5419-55-6 Triisopropyl borate 
• 175278-09-8 4-bromo-2-(trifluoromethoxy)aniline 
• 1535-75-7 2-trifluoromethoxy aniline 
• 150-46-9 triethyl borate 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

2-PYRIDONE COMPOUNDS

A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

INDOLES USEFUL IN THE TREATMENT OF INFLAMATION

There is provided compounds of formula (I), Wherein T, Y, X1 , R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.