902768-55-2 Usage
Description
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine, also known as Maytansinoid DM4 Impurity 2, is a derivative of the natural product maytansine. It is an impurity found in Maytansinoid DM4 (M198505), which is a cytotoxic agent used in the development of antibody-drug conjugates for cancer treatment.
Uses
Used in Pharmaceutical Industry:
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine is used as a cytotoxic agent for the development of antibody-drug conjugates. It is specifically used in the potential treatment of cancer, where it can be linked to antibodies that target specific cancer cells, allowing for the delivery of the cytotoxic agent directly to the tumor site.
As an Impurity in Maytansinoid DM4:
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine is an impurity found in Maytansinoid DM4, which is a cytotoxic agent used in the development of antibody-drug conjugates. The presence of this impurity may affect the efficacy and safety of the final product, and therefore, it is important to monitor and control its levels during the manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 902768-55-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,2,7,6 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 902768-55:
(8*9)+(7*0)+(6*2)+(5*7)+(4*6)+(3*8)+(2*5)+(1*5)=182
182 % 10 = 2
So 902768-55-2 is a valid CAS Registry Number.
902768-55-2Relevant articles and documents
Method for the preparation of maytansinoid esters
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Page/Page column 8; 9, (2008/06/13)
Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.
