90300-22-4

Basic information

• Product Name: 1H-Benzimidazole, 5,6-dichloro-2-phenyl-
• Synonyms: 5,6-Dichlor-2-phenyl-1H-benzimidazol;1H-Benzimidazole,5,6-dichloro-2-phenyl;5,6-dichloro-2-phenyl-1H-benzo[d]imidazole
• CAS NO: 90300-22-4
• Molecular Formula: C13H8Cl2N2
• Molecular Weight: 263.126
• Mol File: 90300-22-4.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 5,6-dichloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 5,6-dichloro-2-phenyl-(90300-22-4)
• EPA Substance Registry System: 1H-Benzimidazole, 5,6-dichloro-2-phenyl-(90300-22-4)

Safety Data

• Hazardous Substances Data: 90300-22-4(Hazardous Substances Data)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 100-46-9 benzylamine 
• 100-51-6 benzyl alcohol 
• 95-76-1 m,p-dichloroaniline 
• 698-16-8 benzohydroximoyl chloride 
• 6641-64-1 4,5-dichloro-2-nitroaniline 
• 100-39-0 benzyl bromide 
• 220185-63-7 4,5-dichloro-2-iodobenzenamine 
• 1940-30-3 2-bromo-4,5-dichloroaniline 
• 611-73-4 Benzoylformic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 31378-03-7 1-phenyl-2-tosylethanone 

Downstream Products

• 1417819-34-1 9,10-dichloro-6-(p-tolyl)benzo[4,5]imidazo[2,1-a]isoquinoline 
• 1417819-30-7 9,10-dichloro-6-phenylbenzo[4,5]imidazo[2,1-a]isoquinoline 

Relevant articles and documents

2-Phenyl-1H-benzimidazole derivative and its application

The present invention belongs to the field of organic chemistry technology, specifically relates to a 2-phenyl-1H- benzimidazole derivative and its applications, the general structural formula as shown in formula (I): wherein R1, R2, R3, R4 are independently selected from hydrogen, halogen, hydroxyl, nitro or alkoxy; R5, R6, R7 Independently selected from hydrogen, hydroxyl or halogen, respectively; the small molecules of the present invention have a significant binding effect with the FTO protein, inhibiting the activity of FTO demethylase, showing good inhibitory activity on leukemia cells and inhibiting the function of renal transparent cell carcinoma.

Solvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles and 1,3,5-triarylbenzenes via the annulation of 2-amino anilines and aryl alkyl ketones or the cyclization of aryl alkyl ketones, respectively. With 1,4-dioxane as the solvent, sequential C[sbnd]N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.

Visible light promoted tandem dehydrogenation-deaminative cyclocondensation under aerobic conditions for the synthesis of 2-aryl benzimidazoles/quinoxalines fromortho-phenylenediamines and arylmethyl/ethyl amines

Visible light promoted domino synthesis of 2-aryl benzimidazoles is reported through the reaction ofortho-phenylenediamines and arylmethyl amines under aerobic conditions. The methodology has wide substrate scope and tolerates a wide range of functional groups affording the products in high yields. The use of arylethyl amines instead of arylmethyl amines gives 2-aryl quinoxalines.