9031-54-3

Basic information

• Product Name: SPHINGOMYELINASE
• Synonyms: SPHINGOMYELINASE;SPHINGOMYELINASE, STAPHYLOCOCCUS AUREUS;SPHINGOMYELIN CHOLINE PHOSPHOHYDROLASE;SPHINGOMYELIN PHOSPHODIESTERASE;EC 3.1.4.12;sphingomyelinase from human placenta;Sphingomyelinase C;SPHINGOMYELINASE FROM STAPHYLOCOCCUS*AUR EUS
• CAS NO: 9031-54-3
• Molecular Weight: 0
• EINECS: 232-869-9
• Mol File: 9031-54-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SPHINGOMYELINASE(CAS DataBase Reference)
• NIST Chemistry Reference: SPHINGOMYELINASE(9031-54-3)
• EPA Substance Registry System: SPHINGOMYELINASE(9031-54-3)

Safety Data

• Hazard Codes: B
• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 9031-54-3(Hazardous Substances Data)

Usage

Description

SPHINGOMYELINASE, also known as sphingomyelin phosphodiesterase, is an enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine. It plays a crucial role in the metabolism of sphingolipids and is involved in various biological processes, including cell signaling, membrane dynamics, and lipid homeostasis.
Source:
SPHINGOMYELINASE can be sourced from various organisms, including Bacillus cereus and Staphylococcus aureus.
Production Methods:
The production of SPHINGOMYELINASE typically involves the extraction and purification of the enzyme from its source organism, followed by further processing to obtain the desired level of purity and activity.

Uses

Used in Skin Care Industry:
SPHINGOMYELINASE is used as a moisturizing agent for enhancing the skin's moisture retention properties. It helps to maintain the skin's natural barrier function and improve its overall health and appearance.
Used in Neuroscience Research:
SPHINGOMYELINASE from Bacillus cereus is used as a tool in the measurement of membrane capacitance in brain slices, which is essential for understanding the biophysical properties of neurons and their response to various stimuli.
Used in Entomology Research:
SPHINGOMYELINASE from Bacillus cereus has been used for testing and confirming its silkworm-killing activity, providing valuable insights into the development of novel insecticides and pest control strategies.
Used in Enzyme Activity Assays:
SPHINGOMYELINASE from Bacillus cereus is used in enzyme activity assays to study its effect on the hydrolysis of sphingomyelin in complex lipid mixtures, which is crucial for understanding the enzyme's mechanism of action and potential applications.
Used in Neuropharmacology Research:
SPHINGOMYELINASE from Staphylococcus aureus is used to induce neurotoxicity in rat cortical cultures, allowing researchers to study the protective effects of drugs like minocycline and develop new therapeutic strategies for neurodegenerative diseases.
Used in Clinical Diagnostics:
SPHINGOMYELINASE from Staphylococcus aureus is used to determine the concentration of sphingomyelin from serum samples, which can be an important biomarker for various diseases and conditions.
Used in Cell Biology Research:
SPHINGOMYELINASE from Staphylococcus aureus is used to enhance sphingomyelinase activity and study PARK9-mediated exosome biogenesis, providing valuable insights into the role of sphingolipids in cellular processes and their potential as therapeutic targets.

Biochem/physiol Actions

Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.