90322-49-9

Basic information

• Product Name: 8-Nitro-4-chromanone
• Synonyms: 8-Nitro-4-chromanone;8-nitro-2,3-dihydrochromen-4-one
• CAS NO: 90322-49-9
• Molecular Formula: C9H7NO4
• Molecular Weight: 193.15618
• Mol File: 90322-49-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.8°C at 760 mmHg
• Flash Point: 191.2°C
• Appearance: /
• Density: 1.424g/cm³
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 8-Nitro-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nitro-4-chromanone(90322-49-9)
• EPA Substance Registry System: 8-Nitro-4-chromanone(90322-49-9)

Safety Data

• Hazardous Substances Data: 90322-49-9(Hazardous Substances Data)

Usage

Description

8-Nitro-4-chromanone, also known as nitrochromanone, is a chemical compound with the molecular formula C9H7NO4. It is a yellow crystalline solid that is used in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical and Agrochemical Industries:
8-Nitro-4-chromanone is used as a building block for the preparation of pharmaceuticals and agrochemicals, as it contains a nitro group which can be easily transformed into other functional groups through chemical reactions.
Used in Antioxidant and Antibacterial Applications:
8-Nitro-4-chromanone is used as an antioxidant and antibacterial agent due to its potential biological and pharmacological properties.
Used in Environmental and Biological Research:
8-Nitro-4-chromanone is used as a fluorescent probe for sensing heavy metal ions in environmental and biological samples, making it a valuable tool for research and analysis.

InChI:InChI=1/C9H7NO4/c11-8-4-5-14-9-6(8)2-1-3-7(9)10(12)13/h1-3H,4-5H2

Upstream product

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Relevant articles and documents

Structurally-thrifty and visible-absorbing fluorophores

Fluorophores with a minimal push-pull backbone are actively pursued due to their potentials in biological labelling. Herein a series of structurally-thrifty and visible-absorbing fluorophores (SDXs) were successfully constructed following the D′D-π-A design strategy, in which a secondary donor (D′) was introduced in conjugation with the donor (D) to enhance its electron donating capability. For a very small scaffold, SDXs exhibit a surprisingly long-wavelength absorption band in the visible spectral range (λabs = 420 nm) and a strong green fluorescence emission (λem = 530 nm) with a fluorescence quantum yield up to 0.84. Notably, fluorescence of SDXs was quenched in hydrogen-bonding solvents, e.g. MeOH and H2O. This phenomenon renders SDXs feasibility for imaging of cellular non-hydrogen-bonding microenvironment, as demonstrated with BEAS-2B cells. These results proved that the D′D-π-A is a powerful design strategy to construct novel structurally-thrifty fluorophores.

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined using pharmacokinetic/pharmacodynamic model predictions of the in vivo hypoxic potency (AUCreq) and selectivity (HCD) with 12 TTO analogues predicted to be active in vivo, subject to the achievement of adequate plasma pharmacokinetics.