90332-63-1

Basic information

• Product Name: 7-Xylosyl-10-deacetyltaxol
• Synonyms: 7-XYLOSYL-10-DEACETYLTAXOL;7-XYLOXYL-10-DEACETYL TAXOL;10-Deacetyltaxol 7-xyloside;b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester;10-Deacetylpaclitaxel 7-Xyloside;DEACETYL-7-XYLOTAXOL, 10-(P);10-Deacetyl-7-xylosyl Paclitaxel (62%);Benzenepropanoic acid, b-(benzoylaMino)-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-Methano-1H-cyclo
• CAS NO: 90332-63-1
• Molecular Formula: C50H57NO17
• Molecular Weight: 943.99
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 90332-63-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 1068.4 °C at 760 mmHg
• Flash Point: 599.9 °C
• Appearance: /
• Density: 1.46 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
• PKA: 11.26±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 7-Xylosyl-10-deacetyltaxol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Xylosyl-10-deacetyltaxol(90332-63-1)
• EPA Substance Registry System: 7-Xylosyl-10-deacetyltaxol(90332-63-1)

Safety Data

• Hazardous Substances Data: 90332-63-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 90332-63-1 differently. You can refer to the following data:
1. A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.
2. A metabolite of Paclitaxel (P132500).

Downstream Products

• 157664-03-4 7-β-D-xylosylbaccatin III 

Relevant articles and documents

Preparation method of 7-xylosyltaxol

The invention relates to a preparation method of 7-xylosyltaxol, and belongs to the technical field of preparation of taxane anticancer drugs, the preparation method comprises the following steps: S1, dissolving a 7-xylosyl-10-deacetylpaclitaxel extract with dichloromethane and pyridine, dropwise adding 2,2,2-trichloroethyl chloroformate while stirring, and reacting to obtain a product I; S2, dissolving the product I in methanol and acetic acid, adding zinc powder, and stirring for reaction to obtain a product II; S3, dissolving the product II in tetrahydrofuran, adding cerium trichloride, dropwise adding acetic anhydride, and stirring for reaction to obtain a product III; and S4, dissolving the product III in methanol, adding a 30% dimethylamine methanol solution, and carrying out a stirring reaction to obtain the 7-xylosyltaxol. The method has the advantages of accessibility of initial materials, mild reaction conditions and high purity of target products, and can be used for large-scale preparation.