903594-00-3Relevant articles and documents
A convenient synthesis of oxazolidinone derivatives linezolid and eperezolid from (S)-glyceraldehyde acetonide
Guangyu, Xu,Yi, Zhou,Chunhao, Yang,Yuyuan, Xie
, p. 316 - 319 (2008)
A new convenient method for the synthesis of oxazolidinone antibacterials Linezolid and Eperezolid from readily available (S)-glyceraldehyde acetonide was developed. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH4 and 4 A sieve, followed by hydrolysis and regioselective cyclization.