903886-78-2

Basic information

• Product Name: 3-Butyn-2-amine, 4-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-
• CAS NO: 903886-78-2
• Molecular Formula: C16H18N2O2S
• Molecular Weight: 302.397
• Mol File: 903886-78-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Butyn-2-amine, 4-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-2-amine, 4-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-(903886-78-2)
• EPA Substance Registry System: 3-Butyn-2-amine, 4-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-(903886-78-2)

Safety Data

• Hazardous Substances Data: 903886-78-2(Hazardous Substances Data)

Upstream product

• 123-31-9 hydroquinone 
• 903886-65-7 5-bromo-2-(4-isopropoxy-phenoxy)-thiazole 
• 7495-77-4 4-isopropoxyphenol 
• 929118-52-5 5-iodo-2-(4-isopropoxyphenoxy)thiazole 
• 929118-32-1 2-(4-isopropoxyphenoxy)thiazole 
• 903886-66-8 2-{3-[2-(4-isopropoxyphenoxy)thiazol-5-yl]-1-methyl-prop-2-ynyl}isoindole-1,3-dione 

Downstream Products

• 904962-72-7 {3-[2-(4-Isopropoxy-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-carbamic acid 4-nitro-phenyl ester 

Relevant articles and documents

The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

The structure-activity relationship study focused on the polar region of the HTS hit A-80040 (1) producing several series of potent and selective ACC2 inhibitors. The SAR suggests a compact lipophilic pocket that does not tolerate polar and ionic groups.

Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.