90389-39-2

Basic information

• Product Name: 1667-16-9
• CAS NO: 90389-39-2
• Molecular Formula: C₁₅H₂₅N
• Molecular Weight: 255.831
• Mol File: 90389-39-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1667-16-9(CAS DataBase Reference)
• NIST Chemistry Reference: 1667-16-9(90389-39-2)
• EPA Substance Registry System: 1667-16-9(90389-39-2)

Safety Data

• Hazardous Substances Data: 90389-39-2(Hazardous Substances Data)

Usage

Chemical Class

Chlorinated thiazole compound

Use

Building block in chemical synthesis for pharmaceuticals, agrochemicals, and fine chemicals

Physical State

Clear, colorless to light yellow liquid

Odor

Pungent

Natural Occurrence

Not known to occur naturally, synthesized in a laboratory

Hazardous Classification

Classified as a hazardous substance

Safety Precautions

Must be handled with proper safety precautions

Upstream product

• 20172-40-1 N-benzylidene-1-octaneamine 
• 100-52-7 benzaldehyde 
• 128297-82-5 N-(1-benzotriazolyl-benzyl)-N-octyl-amino-aceton itrile 
• 128297-78-9 N-(1-benzotriazolyl-methyl)-N-octyl-amino-aceton itrile 
• 128297-87-0 N-benzyl-N-octyl-amino-acetonitrile 
• 73339-13-6 n-octylaminoacetonitrile 
• 111-86-4 n-Octylamine 
• 126541-68-2 N-<(benzotriazol-1-yl)methyl>octylamine 

Downstream Products

• 1558953-48-2 1-(N-(N^α,N^ε-di-Boc-Lys)-N-octylamino)methylbenzene 

Relevant articles and documents

Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

Due to emerging resistance there is a steady need for new antimalarial drugs. Here, we report a new class of water soluble, non-toxic compounds, aryl-alkyl-lysines, with promising activity against the ring stage of Plasmodium falciparum. The optimal compound perturbed the plasma membrane potential and the digestive vacuole of parasites. In the murine model of malaria (Plasmodium berghei ANKA) the compound was able to increase the survival of mice by at least 5 days by an intra-peritoneal route. Further, the compounds showed no apparent toxicity to mice at the concentration tested.

Small molecular antibacterial peptoid mimics: The simpler the better!

The emergence of multidrug resistant bacteria compounded by the depleting arsenal of antibiotics has accelerated efforts toward development of antibiotics with novel mechanisms of action. In this report, we present a series of small molecular antibacterial peptoid mimics which exhibit high in vitro potency against a variety of Gram-positive and Gram-negative bacteria, including drug-resistant species such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. The highlight of these compounds is their superior activity against the major nosocomial pathogen Pseudomonas aeruginosa. Nontoxic toward mammalian cells, these rapidly bactericidal compounds primarily act by permeabilization and depolarization of bacterial membrane. Synthetically simple and selectively antibacterial, these compounds can be developed into a newer class of therapeutic agents against multidrug resistant bacterial species.

Mono-N-alkylation of α-Aminoacetonitriles. A Novel Route to Unsymmetrical Secondary Amines

Mannich-type condensation products of an aldehyde with an α-aminoacetonitrile and benzotriazole are treated with sodium borohydride or with a Grignard reagent to give unsymmetrical N,N-dialkylaminoacetonitriles, which, on decyanomethylation provide unsymmetrical secondary amines.