90411-17-9

Basic information

• Product Name: Kynurenic acid methyl ester
• Synonyms: Kynurenic acid methyl ester
• CAS NO: 90411-17-9
• Molecular Weight: 222.244
• Mol File: 90411-17-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Kynurenic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Kynurenic acid methyl ester(90411-17-9)
• EPA Substance Registry System: Kynurenic acid methyl ester(90411-17-9)

Safety Data

• Hazardous Substances Data: 90411-17-9(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 492-27-3 kinurenic acid 
• 67-56-1 methanol 
• 2922-83-0 L-kynurenine 

Relevant articles and documents

Discovery of kynurenines containing oligopeptides as potent opioid receptor agonists

Kynurenine (kyn) and kynurenic acid (kyna) are well-defined metabolites of tryptophan catabolism collectively known as “kynurenines”, which exert regulatory functions in host-microbiome signaling, immune cell response, and neuronal excitability. Kynurenine containing peptides endowed with opioid receptor activity have been isolated from natural organisms; thus, in this work, novel opioid peptide analogs incorporating L-kynurenine (L-kyn) and kynurenic acid (kyna) in place of native amino acids have been designed and synthesized with the aim to investigate the biological effect of these modifications. The kyna-containing peptide (KA1) binds selectively the μ-opioid receptor with a Ki = 1.08 ± 0.26 (selectivity ratio μ/δ/? = 1:514:10000), while the L-kyn-containing peptide (K6) shows a mixed binding affinity for μ, δ, and ?-opioid receptors, with efficacy and potency (Emax = 209.7 + 3.4%; LogEC50 = ?5.984 + 0.054) higher than those of the reference compound DAMGO. This novel oligopeptide exhibits a strong antinociceptive effect after i.c.v. and s.c. administrations in in vivo tests, according to good stability in human plasma (t1/2 = 47 min).