904894-54-8Relevant articles and documents
Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis
Nagy, Dávid Illés,Grün, Alajos,Lévay, Krisztina,Garadnay, Sándor,Greiner, István,Keglevich, Gy?rgy
, p. 663 - 671 (2018)
The reaction of 1H-imidazol-1-ylacetic acid and two equivalents of phosphorus trichloride/phosphorous acid at 75 °C in sulfolane, or in the presence of catalytic amounts of [bmim][BF4] afforded zoledronic acid in yields up to 75%. The joint use of the ionic liquid additive and sulfolane as the solvent was synergetic affording highly valuable zoledronic acid in a record yield of 93%.
CRYSTALLINE TRIHYDRATE OF ZOLEDRONIC ACID
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Page/Page column 15, (2008/06/13)
Zoledronic acid trihydrate, processes for its preparation, and conversion into zoledronic acid monohydrate.
Crystalline form of zoledronic acid
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Page/Page column 4, (2008/06/13)
Zoledronic acid trihydrate.