904928-69-4Relevant articles and documents
Synthesis of Tetrasubstituted Furans through One-Pot Formal [3 + 2] Cycloaddition Utilizing [1,2]-Phospha-Brook Rearrangement
Aita, Kohei,Ishikawa, Sho,Kondoh, Azusa,Terada, Masahiro
, (2020/03/13)
An efficient method for the synthesis of tetrasubstituted furans was developed by utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis. The two-step one-pot formal [3 + 2] cycloaddition involves the nucleophilic addition of a propargyl anion, which is catalytically generated through the [1,2]-phospha-Brook rearrangement, to an aldehyde and the subsequent intramolecular cyclization mediated by N-iodosuccinimide to provide 2,4,5-trisubstituted-3-iodofurans. The present method with readily available substrates provides new access to a wide range of well-organized tetrasubstituted furans.
Selective oxygenation of alkynes: A direct approach to diketones and vinyl acetate
Xia, Xiao-Feng,Gu, Zhen,Liu, Wentao,Wang, Ningning,Wang, Haijun,Xia, Yongmei,Gao, Haiyan,Liu, Xiang
supporting information, p. 9909 - 9913 (2015/01/09)
Arylalkynes can be converted into α-diketones with the use of a copper catalyst, and also be transformed into vinyl acetates under metal-free conditions, both in the presence of PhI(OAc)2 as an oxidant at room temperature. A series of substituted α-diketones were prepared in moderate to good yields. A variety of vinyl halides could be regio- and stereo-selectively synthesized under mild conditions, and I, Br and Cl could be all easily embedded into the alkynes. This journal is
