90514-72-0

Basic information

• Product Name: 4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE
• Synonyms: ASINEX-REAG BAS 10156674;4-BENZOIMIDAZOL-1-YL-BENZALDEHYDE;4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE;4-(benzimidazol-1-yl)benzaldehyde
• CAS NO: 90514-72-0
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.24
• Mol File: 90514-72-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 428.5 °C at 760 mmHg
• Flash Point: 212.9 °C
• Appearance: /
• Density: 1.19 g/cm³
• PKA: 3.91±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE(90514-72-0)
• EPA Substance Registry System: 4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE(90514-72-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 90514-72-0(Hazardous Substances Data)

Usage

General Description

4-(1H-1,3-benzimidazol-1-yl)benzenecarbaldehyde is a chemical compound with the molecular formula C14H10N2O. It is a benzaldehyde derivative that contains a benzimidazole ring. 4-(1H-1,3-BENZIMIDAZOL-1-YL)BENZENECARBALDEHYDE has potential biological activities and is being studied for its pharmacological properties. It is often used as a building block in organic synthesis and medicinal chemistry. Additionally, it is a part of the chemical structure of some pharmaceutical drugs and is being researched for its potential therapeutic applications.

Upstream product

• 51-17-2 benzoimidazole 
• 459-57-4 4-fluorobenzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 90514-75-3 1-[4-((E)-2-Nitro-propenyl)-phenyl]-1H-benzoimidazole 
• 117607-04-2 6-[(E)-2-(4-Benzoimidazol-1-yl-phenyl)-vinyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one 
• 108122-61-8 1-(4-Benzoimidazol-1-yl-phenyl)-propan-2-one 
• 90514-84-4 5-(4-Benzoimidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 666850-93-7 (4aS,8aR)-2-[1-(4-benzimidazol-1-yl-benzyl)-piperidin-4-yl]-4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride 
• 220495-52-3 4-(benzimidazole-1-yl)benzoic acid 
• 1392592-93-6 4-(4-(1H-benzo[d]imidazol-1-yl) phenyl)-6-(4-methoxyphenyl)pyrimidin-2-amine 
• 1392592-90-3 4-(4-(1H-benzo[d]imidazol-1-yl)phenyl)-6-(4-chlorophenyl)pyrimidin-2-amine 
• 1392592-92-5 4-(4-(1H-benzo[d]imidazol-1-yl) phenyl)-6-(4-bromophenyl)pyrimidin-2-amine 
• 1392592-89-0 4-(4-(1H-benzo[d]imidazol-1-yl)phenyl)-6-(4 fluorophenyl)pyrimidin-2-amine 
• 1392592-91-4 4-(4-(1H-benzo[d]imidazol-1-yl)phenyl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine 

Relevant articles and documents

Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl) phenyl]-1H-benzimidazoles

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13-22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4-12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evalu

PROTEIN-PROTEIN INTERACTION STABILIZERS

Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.

Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions

The stabilization of protein complexes has emerged as a promising modality, expanding the number of entry points for novel therapeutic intervention. Targeting proteins that mediate protein-protein interactions (PPIs), such as hub proteins, is equally challenging and rewarding as they offer an intervention platform for a variety of diseases, due to their large interactome. 14-3-3 hub proteins bind phosphorylated motifs of their interaction partners in a conserved binding channel. The 14-3-3 PPI interface is consequently only diversified by its different interaction partners. Therefore, it is essential to consider, additionally to the potency, also the selectivity of stabilizer molecules. Targeting a lysine residue at the interface of the composite 14-3-3 complex, which can be targeted explicitly via aldimine-forming fragments, we studied the de novo design of PPI stabilizers under consideration of potential selectivity. By applying cooperativity analysis of ternary complex formation, we developed a reversible covalent molecular glue for the 14-3-3/Pin1 interaction. This small fragment led to a more than 250-fold stabilization of the 14-3-3/Pin1 interaction by selective interfacing with a unique tryptophan in Pin1. This study illustrates how cooperative complex formation drives selective PPI stabilization. Further, it highlights how specific interactions within a hub proteins interactome can be stabilized over other interactions with a common binding motif.

Benzimidazolyl benzaldehyde condensed rhodamine hydrazine hydrate Schiff base and preparation method thereof

The invention belongs to the field of fluorescent probes, and particularly relates to a benzimidazolyl benzaldehyde rhodamine hydrazine hydrate Schiff base fluorescent probe. A fluorescent switch is turned on in the presence of iron ions by utilizing a ph