90566-53-3

Basic information

• Product Name: Fluticasone
• Synonyms: (6s,9s,10s,11s,13s,14s,16r,17r)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;FLUTICASONE;FluticasonePropionate98.5%;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-;6α,9-Difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester;6α,9-Difluoro-16α-methyl-11β-hydroxy-17-hydroxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(fluoromethyl) ester;Fluticasone Dipropionate;Androsta-1,4-diene-17- Carbothioic acid, 6,9-difluoro- 11,17-dihydroxy-16-Methyl-3- oxo-, S-(fluoroMethyl) ester, (6α,11β,16α,17α)-
• CAS NO: 90566-53-3
• Molecular Formula: C25H31F3O5S
• Molecular Weight: 500.57
• Product Categories: API
• Mol File: 90566-53-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 237-239 °C
• Boiling Point: 553.2 °C at 760 mmHg
• Flash Point: 288.4 °C
• Appearance: /
• Density: 1.37 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: 11.66±0.70(Predicted)
• Stability: Hygroscopic, Unstable in Solution
• CAS DataBase Reference: Fluticasone(CAS DataBase Reference)
• NIST Chemistry Reference: Fluticasone(90566-53-3)
• EPA Substance Registry System: Fluticasone(90566-53-3)

Safety Data

• Hazardous Substances Data: 90566-53-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 90566-53-3 differently. You can refer to the following data:
1. therapeutic for asthma and allergic rhinitis Flonase
2. Fluticasone is an inhaled corticosteroid used in the treatment of respiratory diseases.

Definition

ChEBI: A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.

Brand name

Cutivate (Altana); Flonase (GlaxoSmithKline); Flovent (GlaxoSmithKline).

InChI:InChI=1/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14?,16+,17+,19+,20+,21+,22+/m1/s1

Upstream product

• 1174034-80-0 S-iodomethyl 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate 

Downstream Products

• 65429-42-7 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid 

Relevant articles and documents

Synthesis of substances related to Fluticasone propionate

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