905716-25-8

Basic information

• Product Name: Pyrimidine, 2-ethoxy-4-methoxy-5-methyl- (9CI)
• Synonyms: Pyrimidine, 2-ethoxy-4-methoxy-5-methyl- (9CI)
• CAS NO: 905716-25-8
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.19308
• Product Categories: PYRIMIDINE
• Mol File: 905716-25-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 2-ethoxy-4-methoxy-5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-ethoxy-4-methoxy-5-methyl- (9CI)(905716-25-8)
• EPA Substance Registry System: Pyrimidine, 2-ethoxy-4-methoxy-5-methyl- (9CI)(905716-25-8)

Safety Data

• Hazardous Substances Data: 905716-25-8(Hazardous Substances Data)

Upstream product

• 64-67-5 diethyl sulfate 
• 25902-89-0 4-methoxy-5-methyl-pyrimidin-2(1H)-one 

Relevant articles and documents

HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives

The lithium salts of the conjugated bases of 4-methoxy- and 4-acetylamino-2(1H)-pyrimidinones 1-3 undergo highly chemoselective N1-methylation or ethylation when treated with methyl- or ethylsulfate (hard electrophiles) in dry dioxane, while the use of DMF as solvent results in competitive O2-alkylation. Potassium salts of the same bases in DMF undergo prevalent O2-attack. Under the same conditions, a similar but less chemoselective behaviour is observed in alkylation of thymine and uracil, where some N3-attack occurs. This can be rationalised in terms of the HSAB principle.