906067-45-6

Basic information

• Product Name: Methanone, (4-bromophenyl)-9H-pyrido[3,4-b]indol-1-yl-
• CAS NO: 906067-45-6
• Molecular Formula: C18H11BrN2O
• Molecular Weight: 351.202
• Mol File: 906067-45-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (4-bromophenyl)-9H-pyrido[3,4-b]indol-1-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-bromophenyl)-9H-pyrido[3,4-b]indol-1-yl-(906067-45-6)
• EPA Substance Registry System: Methanone, (4-bromophenyl)-9H-pyrido[3,4-b]indol-1-yl-(906067-45-6)

Safety Data

• Hazardous Substances Data: 906067-45-6(Hazardous Substances Data)

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 61-54-1 tryptamine 
• 5195-29-9 4-bromophenylglyoxal 
• 73-22-3 L-Tryptophan 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 922525-65-3 [1,1'-biphenyl]-4-yl(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 922525-74-4 C₂₈H₂₄N₂O 
• 922525-77-7 C₃₀H₂₀N₂O 
• 922525-68-6 C₂₅H₁₈N₂O 
• 922525-71-1 C₂₄H₁₅FN₂O 

Relevant articles and documents

Preparation method of 1-carbonyl-beta-carboline compound

The invention discloses a preparation method of a 1-carbonyl-beta-carboline compound. The preparation method comprises the following step: in an air or oxygen atmosphere, in the presence of an additive and under the condition of illumination, performing oxidation reaction on tetrahydrocarboline compound as shown in a formula II to obtain the 1-carbonyl-beta-carboline compound as shown in a formula I, wherein the additive is tetrabutyl quaternary ammonium salt selected from any one of tetrabutylammonium bromide, tetrabutylammonium iodide, tetrabutylammonium chloride, tetrabutylammonium acetate and tetrabutylammonium fluoride; and the molar ratio of the tetrahydrocarboline compound as shown in the formula II to the additive is 1:(0.2-2). The preparation method provided by the invention is high in yield, wherein most of the yield is between 60% and 90%. When R3 is an aromatic group, the variety and the position of a substituent group on an aromatic ring do not have substantial influence on the yield of the reaction. In addition, the R3 group has wider applicability and also comprises an alkyl R3 group besides the aromatic R3 group, and in this aspect, the preparation method provided by the invention is substantially improved compared with the existing synthesis.

A cascade coupling strategy for one-pot total synthesis of β-carboline and isoquinoline-containing natural products and derivatives

Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme). Copyright

Regioselective photo-oxidation of 1-benzyl-4,9-dihydro-3H-β-carbolines

The synthesis of a series of β-carboline-based analogues of the natural product fascaplysin is presented; the compounds were produced using a novel photo-oxidation reaction of 1-benzyl-4,9-dihydro-3H-β-carbolines as the key step. The Royal Society of Chemistry 2006.