906096-92-2Relevant articles and documents
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of γ-aminobutyric acid (GABA) related compounds
Lolli, Marco L.,Hansen, Suzanne L.,Rolando, Barbara,Nielsen, Birgitte,Wellendorph, Petrine,Madsen, Karsten,Larsen, Orla Miller,Kristiansen, Uffe,Fruttero, Roberta,Gasco, Alberto,Johansen, Tommy N.
, p. 4442 - 4446 (2007/10/03)
Three 4-substituted 1,2,5-oxadiazol-3-ols containing aminoalkyl substituents (analogues and homologues of γ-aminobutyric acid (GABA)) were synthesized to investigate the hydroxy-1,2,5-oxadiazolyl moiety as a bioisoster for a carboxyl group at GABA recepto