906370-55-6

Basic information

• Product Name: 13-O-[[(4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-yl]carbonyl]-7-O-triethylsilylbaccatin III
• Synonyms: 13-O-[[(4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-yl]carbonyl]-7-O-triethylsilylbaccatin III
• CAS NO: 906370-55-6
• Molecular Weight: 1010.22
• Mol File: 906370-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 13-O-[[(4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-yl]carbonyl]-7-O-triethylsilylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 13-O-[[(4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-yl]carbonyl]-7-O-triethylsilylbaccatin III(906370-55-6)
• EPA Substance Registry System: 13-O-[[(4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-yl]carbonyl]-7-O-triethylsilylbaccatin III(906370-55-6)

Safety Data

• Hazardous Substances Data: 906370-55-6(Hazardous Substances Data)

Upstream product

• 244760-98-3 (4S,5R)-3-N-benzoyl-4-phenyloxazolidin-2RS-methoxy-5-carboxylic acid 
• 115437-21-3 7-(triethylsilyl)baccatin III 

Downstream Products

• 33069-62-4 taxol 

Relevant articles and documents

Method for Preparing Paclitaxel

The invention concerns a method for preparing paclitaxel characterized in that it consists in starting with 10-deacety)-baccatine in accordance with a “one-pot” reaction including the following three steps: a) protecting the hydroxy radical in position 7 of 10-deacetylbaccatine with a silylated radical, then b) acetylating the hydroxy radical in position 10, c) optionally crystallizing the resulting baccatine III derivative, followed by condensation of (4S,5R)-3-N-benzoyl-2RS-methoxy-4-phenyl-1,3-oxazolidine-5-carboxylic acid, by esterifying in position 13 the acetylated 10-baccatine III derivative previously obtained, then opening the oxazolidine of the cyclic side chain and simultaneously releasing the hydroxy radical in position 7.