906532-81-8

Basic information

• Product Name: 1-benzyl-1-(2-chloro-4-fluoro-phenyl)urea
• Synonyms: 1-benzyl-1-(2-chloro-4-fluoro-phenyl)urea
• CAS NO: 906532-81-8
• Molecular Weight: 278.713
• Mol File: 906532-81-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-1-(2-chloro-4-fluoro-phenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-1-(2-chloro-4-fluoro-phenyl)urea(906532-81-8)
• EPA Substance Registry System: 1-benzyl-1-(2-chloro-4-fluoro-phenyl)urea(906532-81-8)

Safety Data

• Hazardous Substances Data: 906532-81-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 2106-02-7 2-chloro-4-fluoroaniline 
• 906371-83-3 benzyl-(2-chloro-4-fluorophenyl)amine 

Downstream Products

• 906532-86-3 1-benzyl-5-fluoro-1,3-dihydro-2H-benzo[d]imidazol-2-one 

Relevant articles and documents

Efficient access to cyclic ureas via Pd-catalyzed cyclization

An efficient regioselective method for the preparation of structurally diverse imidazopyridinones and benzoimidazolones starting from readily available and economical starting materials is described. High-yielding reductive alkylation of electron-deficient o-haloarylamines followed by treatment with inexpensive N-chlorosulfonyl isocyanate afforded primary ureas in good overall yields. A Pd-catalyzed urea cyclization reaction furnished imidazopyridinones and benzoimidazolones in excellent yields. Overall, the developed chemistry provides rapid access to pharmaceutically important heterocyclic compounds with high efficiency.