90678-69-6

Basic information

• Product Name: N-(2-phenylethyl)pyridin-2-amine
• Synonyms: N-(2-phenylethyl)pyridin-2-amine;90678-69-6;N-Phenethylpyridine-2-amine;SCHEMBL15904158;DTXSID90395119;2-(N-benzyl-N-methyl)aminopyridine;AKOS008922435
• CAS NO: 90678-69-6
• Molecular Weight: 198.268
• Mol File: 90678-69-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: N-(2-phenylethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-phenylethyl)pyridin-2-amine(90678-69-6)
• EPA Substance Registry System: N-(2-phenylethyl)pyridin-2-amine(90678-69-6)

Safety Data

• Hazardous Substances Data: 90678-69-6(Hazardous Substances Data)

Usage

Description

N-(2-phenylethyl)pyridin-2-amine, also known as 2-(β-phenylethyl)pyridin-2-amine, is a chemical compound belonging to the class of pyridines. It features a pyridine ring with an amine group at the second position and a phenylethyl group attached to the nitrogen atom. N-(2-phenylethyl)pyridin-2-amine exhibits potential biological activity and has been investigated for its therapeutic applications, particularly in the treatment of central nervous system disorders. Its affinity for specific neurotransmitter receptors in the brain positions it as a promising candidate for further research and pharmaceutical development, with potential applications in medicinal chemistry for creating new drugs with neuroprotective or psychoactive properties.

Uses

Used in Pharmaceutical Development:
N-(2-phenylethyl)pyridin-2-amine is utilized as a lead compound in the development of new drugs targeting central nervous system disorders. Its interaction with neurotransmitter receptors suggests potential neuroprotective or psychoactive properties, making it valuable for creating medications aimed at treating various neurological conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(2-phenylethyl)pyridin-2-amine serves as a key subject of study. Researchers explore its structure-activity relationships and potential modifications to enhance its therapeutic effects, thereby contributing to the advancement of drug discovery and the creation of more effective treatments for neurological disorders.

Upstream product

• 372-48-5 2-fluoropyridine 
• 64-04-0 phenethylamine 
• 504-29-0 2-aminopyridine 
• 100-42-5 styrene 
• 109-09-1 2-chloropyridine 
• 109-04-6 2-bromo-pyridine 
• 34420-17-2 (2-phenylethyl)boronic acid 
• 60-12-8 2-phenylethanol 
• 103-63-9 1-phenyl-2-bromoethane 
• 111098-20-5 N-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)pyridin-2-amine 
• 6921-34-2 benzylmagnesium chloride 
• 142-08-5 2-Pyridone 
• 40825-17-0 Natrium-Verbindung des [2]Pyridylamins 
• 5029-67-4 2-iodopyridine 

Relevant articles and documents

Rhodium(I) N-heterocyclic carbene complexes as catalysts for the anti-markovnikov hydroaminations of styrene

A series of new rhodium(I) complexes with benzimidazole based N-heterocyclic carbene (NHC) ligand were synthesized by reactions of benzimidazolium salts with [Rh(OMe)COD]2. The characterization of rhodium(I) complexes with the general formula [RhCl(NHC)(4-1,5-cyclooctadiene)] was done by physicochemical and spectroscopic methods. All the synthesized complexes were tested as catalysts in the intermolecular hydroamination reactions between styrene with aromatic amines in ionic liquid. All of these complexes tested here are catalytically active for the intermolecular hydroamination of styrene with aromatic amines in ionic liquid. The anti-Markovnikov addition products were obtained selectively by using 1 mol% of the rhodium complex.

Ruthenium(II) complexes with chelating n-heterocyclic carbenes and a ruthenate(II) complex as catalysts for the anti-Markovnikov hydroaminations of styrene

New ruthenium chelate and ruthenate complexes were synthesized through the reaction of benzimidazolium salts and [RuCl2(p-cymene)]2 in toluene and characterized by elemental analysis, 1H NMR and 13C NMR spectroscopy. These ruthenium complexes were tested as catalysts in the intermolecular hydroamination reactions between styrene with aromatic amines in ionic liquid. All of these complexes tested here showed good catalytic activity in these reactions. The hydroamination reactions regioselectively produced anti-Markovnikov addition products in moderate to good yields by using 1 mol% of the ruthenium complex.

Anti-Markovnikov hydroaminations of styrene catalyzed by palladium(II) N-heterocyclic carbene complexes under conventional and microwave heating

Six palladium(II) complexes with benzimidazole-based N-heterocyclic carbene ligands were synthesized by transmetallation reactions between silver(I) N-heterocyclic carbene complexes and PdCl2(PhCN)2. The complexes were characterized by physicochemical and spectroscopic methods. The palladium complexes were tested as catalysts for intermolecular hydroamination reactions of styrene with various anilines in ionic liquids under both conventional and microwave heating. All of these complexes proved to be catalytically active in these reactions. The anti-Markovnikov addition products were selectively obtained by using 1?mol% of the palladium complex.