90731-57-0

Basic information

• Product Name: N-BOC-ERYTHRO-L-BETA-METHYLPHENYLALANINE
• Synonyms: (2S,3S)-BOC-BETA-METHYL-PHENYLALANINE;(2S,3S)-N-BOC-2-AMINO-3-PHENYL-BUTYRIC ACID;N-(TERT-BUTOXYCARBONYL)-ERYTHRO-L-BETA-METHYLPHENYLALANINE;N-BOC-ERYTHRO-L-BETA-METHYLPHENYLALANINE;N-Boc-erythro-L-β-methylphenylalanine;N-BOC-erythro-L-beta-Methylphenylalanine,97%;(2s,3s)-3-phenyl-2-(tert-butoxycarbonylaMino) butanoate;(2S,3S)-2-((tert-Butoxycarbonyl)amino)-3-phenylbutanoic acid
• CAS NO: 90731-57-0
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.33
• Mol File: 90731-57-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 100-105 °C
• Boiling Point: 426.8°C at 760 mmHg
• Flash Point: 211.9°C
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• Vapor Pressure: 4.79E-08mmHg at 25°C
• Storage Temp.: 0-6°C
• PKA: 3.90±0.10(Predicted)
• CAS DataBase Reference: N-BOC-ERYTHRO-L-BETA-METHYLPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-ERYTHRO-L-BETA-METHYLPHENYLALANINE(90731-57-0)
• EPA Substance Registry System: N-BOC-ERYTHRO-L-BETA-METHYLPHENYLALANINE(90731-57-0)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 90731-57-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H21NO4/c1-10(11-8-6-5-7-9-11)12(13(17)18)16-14(19)20-15(2,3)4/h5-10,12H,1-4H3,(H,16,19)(H,17,18)/p-1/t10-,12-/m0/s1

Upstream product

• 1449299-79-9 C₂₇H₂₁N₃O₃ 
• 908129-34-0 (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide 
• 128677-95-2 (2S,3S)-2-azido-3-phenylbutanoic acid 
• 1449299-96-0 C₂₄H₂₅N₅O₃ 
• 1449299-94-8 C₁₉H₁₇N₅O 
• 24424-99-5 di-tert-butyl dicarbonate 
• 25488-25-9 (2S,3S)-methylphenylalanine 
• 25488-24-8 (S)-2-Amino-3-phenyl-butyric acid 
• 117918-24-8 (S)-3-Phenyl-2-(2,2,2-trifluoro-acetylamino)-butyric acid 
• 218797-62-7 methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester 
• 218797-66-1 (2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane 
• 198829-58-2 (2S,3R)-1-(tert-butoxycarbonyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>-3-phenylaziridine 
• 153704-74-6 (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol 
• 125414-45-1 (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol 

Downstream Products

• 1352201-93-4 (2S,3S)-2-amino-1-(1,2-oxazinan-2-yl)-3-phenylbutan-1-one, trifluoroacetic acid salt 
• 1258544-67-0 (3S,4S)-3-amino-1-(benzyloxy)-4-methyl-3,4-dihydroquinolin-2(1H)-one 
• 1258544-66-9 tert-butyl (3S,4S)-1-(benzyloxy)-4-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-3-ylcarbamate 
• 1258544-65-8 tert-butyl (2S,3S)-1-(benzyloxyamino)-1-oxo-3-phenylbutan-2-ylcarbamate 
• 1165872-91-2 {(1S,2S)-1-[5-(2-fluoro-4-iodo-phenyl)-1H-imidazol-2-yl]-2-phenyl-propyl}-carbamic acid tert-butyl ester 
• 946089-54-9 C₂₅H₃₂N₂O₇ 
• 876755-69-0 2-((2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyrylamino)-thiazole-4-carboxylic acid methyl ester 
• 676630-29-8 methyl (βS)-N-(tert-butoxycarbonyl)-N,β-dimethyl-L-phenylalaninate 

Relevant articles and documents

Stereoselective synthesis of β-alkylated α-amino acids via palladium-catalyzed alkylation of unactivated methylene C(sp3)-H Bonds with Primary Alkyl Halides

We report a new set of reactions based on the Pd-catalyzed alkylation of methylene C(sp3)-H bonds of aliphatic quinolyl carboxamides with α-haloacetate and methyl iodide and applications in the stereoselective synthesis of various β-alkylated α-amino acids. These reactions represent the first generally applicable method for the catalytic alkylation of unconstrained and unactivated methylene C-H bonds with high synthetic relevance. When applied with simple isotope-enriched reagents, they also provide a convenient and powerful means to site-selectively incorporate isotopes into the carbon scaffolds of amino acid compounds.

Synthesis of N-Boc-β-aryl alanines and of N-Boc-β-methyl-β-aryl alanines by regioselective ring-opening of enantiomerically pure N-Boc- aziridines

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